Sialic acids are part of a larger family of nonulosonic acid (NulO) molecules that includes pseudaminic and legionaminic acids. Microbial expression of sialic acids and other nonulosonic acids has been shown to contribute to host-microbe interactions in a variety of contexts, including ...
Please try again and make sure cookies are enabledReferences 1 A. Varki, R.L. Schnaar, R. Schauer Sialic acids and other nonulosonic acids A. Varki, R.D. Cummings, J.D. Esko, P. Stanley, G.W. Hart, M. Aebi, A.G. Darvill, T. Kinoshita, N.H. Packer, J.H. Prestegard, R...
In addition, a number of other nonulosonic acids are described in proteobacteria among which the 5,7-diamino-3,5,7,9-tetradeoxy-d-glycero-d-galacto-nonulosonic acid (legionaminic acid (Leg)) and the 5,7-diamino-3,5,7,9-tetradeoxy-l-glycero-l-manno-nonulosonic acid (pseudaminic ac...
www.nature.com/scientificreports OPEN Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non‑vegetarian dietary patterns Gerardo N. Guerrero‑Flores 1,2, Fabio J. Pacheco 1,3, Danilo S. Boskovic 4, Sandaly...
Advances in the Biology and Chemistry of Sialic Acids Sialic acids are a subset of nonulosonic acids, which are nine-carbon alpha-keto aldonic acids. Natural existing sialic acid-containing structures are pres... X Chen,A Varki - 《Acs Chemical Biology》 被引量: 495发表: 2010年 ...
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic aci
receptorIntroductionThecellsurfaceisrichlydecoratedinglycansthatareattachedtoproteinsandlipids.Theexposedterminiofoligosaccharidesareoftencappedwithsialicacid—thetermgiventoadiversefamilyofnine-carbonsugarsderivedfromneuraminicacid(Neu)orketo-deoxynonulosonicacid(Kdn).Sialicacidsaretypicallyfoundattachedtoothersugars...
Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009;106:13552–7. ...
Polysialic acids (polySia)* are a structurally diverse family of linear carbohydrate chains that consist of N-acetylneuraminic acid (Neu5Ac) or N-glycolylneuraminic acid (Neu5Gc) residues, usually joined internally by α2,8-, α2,9-, or alternating...
Enzymatic synthesis of sialic acid, KDO, and related deoxyulosonic acids, and of oligosaccharides.Hanessian, S