Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment of sialic acid to the terminal residues of oligosa...
Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment of sialic acid to the terminal residues of oligosa...
13]. One prominent Sia detected in many mammals wasN-glycolylneuraminic acid (Neu5Gc), which differs from the other common SiaN-acetylneuraminic acid (Neu5Ac) by one additional oxygen atom in the acyl group at the C5 position [14]
Inability of HAdV-C5 to bind sialic acid despite apparently conserved residues in the binding pocket To confirm the validity of our structural observations, we used as a negative control of our structural modelling. We used the fiber-knob protein of HAdV-C5 (PDB ID:6HCN) superposed on the ...
The predominant sialic acids on most mammalian cells are N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac). Neu5Gc is notable for its deficiency in humans due to a species-specific and species-universal inactivating deletion in the CMAH gene encoding the hydroxylase ...
In contrast to previous studies, the GC/MS analysis of RBC sialic acid revealed a large diversity of these compounds, especially for glycoprotein-bound sialic acids. Table 1. Distribution of glycoprotein- and glycolipid-bound sialic acids in human erythrocyte membranes of A+, B+, AB+, O+ ...
Sialic acid acetylesterase (SIAE) is an enzyme that negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of immunological tolerance in mice. Heterozygous loss-of-function germline rare variants and a homozygous defective polymorphic variant of SIAE were identifi...
N-acetylneuraminic acid (sialic acid) is found in a wide variety of substances and tissues in animals and humans, occurring most abundantly in glycoproteins and glycolipids. An acidic aminosugar was first isolated and named sialic acid by one scientist. Another isolated a similar crystallized form...
HumansGoblet CellsEpithelial CellsCell LineCiliaInfluenza A virusChemokinesReceptors, Cell SurfaceInfluenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one ...
The neural cell adhesion molecule (NCAM) is modified by polysialic acid (polySia or PSA) in embryonic brains. In adult brains, polySia modification of NCAM is only observed in restricted areas where neural plasticity, remodeling of neural connections, or neural generation is ongoing although the...