Self-replicating RNA vaccine delivery to dendritic cells. In T. Kramps and K. Elbers (editors). RNA Vaccines: Methods and Protocols. Springer Science+Business Media, New York, 2017; vol 1499; pp 37-75.Demoulins, T., Englezou, P.C., Milona, P., Ruggli, N., Tirelli, N., Pichon,...
Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, suggesting this technology may improve immunization. This review will explore how self-amplifying RNAs are emerging as important vaccine candidates for infectious diseases, the advantages of synthetic ...
例句>> 5) self-replicating[英][self'replikeitiŋ] [美]['sɛlf'rɛplɪ,ketɪŋ] 自主复制 例句>> 6) multiple emulsion vaccine 复乳疫苗 补充资料:RNA 见核糖核酸。 说明:补充资料仅用于学习参考,请勿用于其它任何用途。 参考词条
1999. Cancer therapy using a self-replicating RNA vaccine. Nat. Med. 5:823-827.Ying H, Zaks TZ, Wang RF, et al: Cancer therapy using a self-replicating RNA vaccine. Nat Med 5:823-827, 1999Ying H, Zaks TZ, Wang RF, Irvine KR, Kammula US, Marincola FM, Leitner WW, Restifo NP....
This is the first published demonstration of the clinical efficacy of an sa-mRNA vaccine. ARCT-154 had > 90% efficacy against severe COVID-19 in those at risk for severe disease, those aged over 60 years, and adults from 18 to 59 years of age with underlying co-morbidities. Efficacy ...
Cancer therapy using a self-replicating RNA vaccine. 'Naked' nucleic acid vaccines are potentially useful candidates for the treatment of patients with cancer, but their clinical efficacy has yet to be demons... Ying,Han,Zaks,... - 《Nature Medicine》 被引量: 364发表: 1999年 The EigenTrust...
Dr. Daniel Nagase warns of possible GLOBAL CATASTROPHE as Japan plans to roll out world’s first self-replicating mRNA COVID-19 vaccine 08/16/2024/Ava Grace They never learn: Chinese scientists create mutant EBOLA virus 07/22/2024/Lance D Johnson ...
“JCXH-105 has been developed using Immorna’s propriety srRNA platform, which features improved immunogenicity and reactogenicity compared to the standard alphavirus RNA replicon. We chose to use srRNA because compared to the non-replicating conventional mRNA, srRNA strongly modulates T cell ...
While efforts to improve the thermostability of LNP-based vaccines are progressing11–15, non-frozen distribution and sto- rage have yet to be realized with a licensed mRNA vaccine product. Despite efforts, long-term stability of mRNA/LNP systems at non-frozen temperatures may be difficult to ...
Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, heterologous chimpanzee adenovirus (ChAd68) and self-amplifying mRNA (samRNA)-based neoantigen vaccine in combination with nivolumab and ipilimumab were assessed as primary endpoints in an ongoing phase 1/2 study in ...