mRNA deliveryGene deliveryLipid nanoparticlesSelf-assemblyImmunizationCOVID-19mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe...
mRNA疫苗概念现在有$沃森生物(SZ300142)$和$西藏药业(SH600211)$,谁来告诉我其中不包括万泰生物? $BioNTech(BNTX)$其实也早就觊觎$万泰生物(SH603392)$的这个流感疫苗平台了,它没有把这个技术叫做mRNA,而是给了另外一个名字:Sa-RNA(Self-Amplifying RNA Vaccines),并且说Sa-RNA只需要相当于mRNA疫苗64分之1的剂...
RNA vaccines This article is cited by Replicon RNA vaccines: design, delivery, and immunogenicity in infectious diseases and cancer Lirui Tang Haiying Que Xiawei Wei Journal of Hematology & Oncology(2025) Branched chemically modified poly(A) tails enhance the translation capacity of mRNA ...
In face of such an urgent situation, a new generation of SARS-CoV-2 vaccines that are effective against currently known VOCs, especially the Omicron variant, should be developed. In the present study, we reported the development of a self-assembled trimeric RBD subunit vaccine that can ...
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Omicron mutations, while impacting Spike substantially, have minimal impact (~2%) on the T Cell Epitope (TCE) sequences included within Gritstone’s COVID-19 vaccines.
So as Dr. Mihalcea also shows us in this video, while EVERY blood sample they tested, vaxxed and unvaxxed, had these self-assembling rubbery clots within them, with the video actually showing us a microchip being assembled before our very eyes, tests were run upon the...
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommend
Immorna is an innovative drug research company that focuses on developing self-replicating and conventional mRNA-based therapeutics and vaccines. It has maintained stable and fast growth since its incorporation in 2019. Currently, it has built a comprehensive set of mRNA synthesis, purification and an...
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provide...