mRNA deliveryGene deliveryLipid nanoparticlesSelf-assemblyImmunizationCOVID-19mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe...
This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key to realizing the full potential of these vaccines is...
Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences
This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a reference for the design of mRNA vaccines targeting SARS-CoV-2. 展开 DOI: 10.1038/s41392-021-00750-w 年份: 2021 收藏 引用 批量引用 报错 分享 ...
According to Smerdou, even several years of experience with mRNA vaccines “maybe are not translatable to the samRNA.” Additionally, some potentially unresolved concerns surrounding samRNA technology still remain, he says. In particular, he highlights that with samRNA, “you are not only exp...
In face of such an urgent situation, a new generation of SARS-CoV-2 vaccines that are effective against currently known VOCs, especially the Omicron variant, should be developed. In the present study, we reported the development of a self-assembled trimeric RBD subunit vaccine that can ...
So as Dr. Mihalcea also shows us in this video, while EVERY blood sample they tested, vaxxed and unvaxxed, had these self-assembling rubbery clots within them, with the video actually showing us a microchip being assembled before our very eyes, tests were run upon th...
Nanovaccines, a new generation of vaccines that use nanoparticles as carriers and/or adjuvants, have been widely used in the prevention and treatment of various diseases, including cancer. Nanovaccines have sparked considerable interest in cancer therapy
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase 1 of this ran