This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key to realizing the full potential of these vaccines is...
and HIV-1. Self-amplifying RNAs have shown enhanced antigen expression at lower doses compared to conventional mRNA, suggesting this technology may improve immunization. This review will explore how self-amplifying RNAs are emerging as important vaccine candidates for infectious diseases, the advantages...
Self-amplifying vaccines promise extended efficacy with lower doses than their mRNA predecessors, but approvals have been slow to materialize. Credit: Javier Zayas Photography/ Getty Images A year after bursting onto the scene amid the RNA renaissance, scientific challenges and regulatory resistance...
Moreover, it was found that injection of mRNA or plasmid DNA (pDNA) into a mice's skeletal muscle leads the expression of encoded protein.doi:10.1038/nrd3854FlemmingAlexandraNat Rev Drug DiscovNature Reviews Drug DiscoveryVaccines: Self-amplifying RNA in lipid nanoparticles: a next-generation ...
“As for all self-amplifying vaccines, concerns have been raised over adverse events in vulnerable individuals. For example, replicon [sa-mRNA] vaccines could persist in immunocompromised individuals as clearance may be less efficient,” it said. ...
The doses ranged from 0.1 micrograms to 10 micrograms of saRNA , with 87 percent of people generating antibodies to SARS-CoV-2, the virus that causes COVID-19. For comparison, the Moderna and Pfizer mRNA vaccines have dosages of 100 and 30 micrograms, respectively. ...
[3] Bloom et al., (2020). Self-amplifying RNA vaccines for infectious diseases. Gene Therapy, https://doi.org/10.1038/s41434-020-00204-y 注:本文旨在介绍医药健康研究进展,不是治疗方案推荐。如需获得治疗方案指导,请前往正规医院就诊。
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Self-amplifying RNA (saRNA) Revolutionizing Vaccine Development Rapid response to emerging diseases is critical when developing a vaccine. Long RNA (mRNA and saRNA) is at the forefront of vaccine development. Benefits of saRNA saRNA vaccines can be developed in a fraction of the time it takes to...
However, limitations in these vaccines have been recognized due to their requirement for cold storage, short durability of protection, and lack of access in low-resource regions. We have developed an easily-manufactured, potent self- amplifying RNA (saRNA) vaccine against SARS-CoV-2 that is ...