as is evident from the swift pursuit of RNA vaccine candidates for the global SARS-CoV-2 pandemic. Both conventional and self-amplifying RNAs have shown protective immunization in preclinical studies against multiple infectious diseases including influenza, RSV, Rabies, Ebola, and HIV-1. Self-amplif...
Vaccines: Self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?. Flemming Alexandra. Nature reviews. Drug discovery . 2012Flemming A. Vaccines: Self-amplifying RNA in lipid nanoparticles: a next-generation vaccine? Nat Rev Drug Discov. 2012; 11 :748–749. doi: 10.1038/nrd3854....
self-amplifying RNAVEEV vaccineRNA vaccineCNEVenezuelan equine encephalitis virus (VEEV) is a known biological defense threat. A live-attenuated investigational vaccine, TC-83, is available, but it has a high non-response rate and can also cause severe reactogenicity. We generated two novel VEE ...
those used for veterinary applications have been approved for much longer. For example, Ames, Iowa-based Harrisvaccines, now a part of MSD Animal Health, gained USDA approval in 2012 for a samRNA vaccine against swine influenza H3N2 based on its “SirraVax” replicon...
More information:Katrina M. Pollock et al, Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against COVID-19: COVAC1, a Phase I, Dose-Ranging Trial,SSRN Electronic Journal(2021).
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Rapid response to emerging diseases is critical when developing a vaccine. Long RNA (mRNA and saRNA) is at the forefront of vaccine development. Benefits of saRNA saRNA vaccines can be developed in a fraction of the time it takes to develop a conventional vaccine ...
Both mRNA and sa-mRNA are RNA vaccines that use a virus’ genetic code against it. When an mRNA vaccine is injected into an individual, the mRNA instructs cells to make a specific protein and thus stimulates immune response. An sa-mRNA vaccine takes this concep...
Induction of Protective Immunity against Toxoplasma gondii in Mice by Nucleoside Triphosphate Hydrolase-II (NTPase-II) Self-amplifying RNA Vaccine Encapsul... RNA-based vaccine represents an irresistible and safe immunization strategy with decreasing theoretical risks of genomic integration and malignant ...
www.nature.com/npjvaccines ARTICLE OPEN A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability Emily A. Voigt 1 ✉, Alana Gerhardt2, Derek Hanson1, Madeleine F. Jennewein 1, Peter Battisti1, Sierra Reed2, Jasneet Singh1, Raodoh Mohamath3, Julie Bakken...