重磅:自我扩增mRNA(‘self-amplifying’ RNA/saRNA)抗新冠疫苗ARCT-154震撼上市!saRNA可在细胞内自我倍增,也就允许初始接种剂量很小,是常规mRNA疫苗的1/10-1/6,可降低副作用;越来越多研究证明,saRNA不仅用...
It references the article "Nonviral delivery of self-amplifying RNA vaccines," by A. Geall and colleagues in the 2012 issue of the "Proceedings of the National Academy of Sciences" (PNAS). Moreover, it was found that injection of mRNA or plasmid DNA (pDNA) into a mice's skeletal ...
Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences
self-amplifying RNAVEEV vaccineRNA vaccineCNEVenezuelan equine encephalitis virus (VEEV) is a known biological defense threat. A live-attenuated investigational vaccine, TC-83, is available, but it has a high non-response rate and can also cause severe reactogenicity. We generated two novel VEE ...
Revolutionizing Vaccine Development Rapid response to emerging diseases is critical when developing a vaccine. Long RNA (mRNA and saRNA) is at the forefront of vaccine development. Benefits of saRNA saRNA vaccines can be developed in a fraction of the time it takes to develop a conventional vaccine...
The technology usesgenetic codecalled self-amplifying RNA (saRNA). This genetic information holds instructions to make a protein found on the outside of the coronavirus, called the spike protein. Once injected into the muscle of the arm, the cells make this spike protein, enabling the immune sy...
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Duringtestimonyat the European Parliament last month, cardiologist Peter McCullough said that“there’s not a single study showing that the messenger RNA is broken down” in the human body once it is injected.Since the vaccines are “made synthetically, they cannot...
samRNA therapeutics build on standard mRNA vaccines, wherein an mRNA strand encodes a protein presented by a given virus, cancer cell, or other target; this protein is produced within host cells upon vaccination, inducing an immune response. samRNA therapeutics also include RNA encoding a re...
Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle(LNP) as a vaccine. We observe remarkably high and dose-dependent SARS-CoV-2 specific antibody titers in mouse sera, as well as robust neutralization of both a pseudo-virus ...