This urgent public health challenge necessitates the swift development of safe and effective vaccines capable of eliciting robust immune responses at low doses. Addressing this need, our study investigated five
Self-amplifying mRNA (SAM) vaccines can be rapidly deployed in the event of disease outbreaks. A legitimate safety concern is the potential for recombination between alphavirus-based SAM vaccines and circulating viruses. This theoretical risk needs to be assessed in ...
scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences or immunotherapies as synthetic RNA transcripts, which are then formulated for delivery. This approach may enable a quicker respo...
Combination of waning immunity and lower effectiveness against new SARS-CoV-2 variants of approved COVID-19 vaccines necessitates new vaccines. We evaluated two doses, 28 days apart, of ARCT-154, a self-amplifying mRNA COVID-19 vaccine, compared with saline placebo in an integrated phase 1/...
injection technology, today announced the npj Vaccines publication of Gennova Biopharmaceutical’s post hoc analysis of their Phase 3 clinical study, which evaluated the cellular immune breadth induced by their sel...
内容提示: Nonviral delivery of self-amplifying RNA vaccinesAndrew J. Gealla,1, Ayush Vermaa, Gillis R. Ottena, Christine A. Shawa, Armin Hekelea, Kaustuv Banerjeea, Yen Cua,Clayton W. Bearda, Luis A. Britoa, Thomas Kruckerb, Derek T. O’Hagana, Manmohan Singha, Peter W. Masona,...
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
摘要: Self-replicating RNA derived from the genomes of positive strand RNA viruses represents a powerful tool for both molecular studies on virus biology and approaches to novel safe and effective...关键词: Self-replicating RNA Positive strand RNA virus Alphavirus Flavivirus Pestivirus Classical ...
1 Therefore, the capacity to rapidly develop vaccines against emerging viruses needs to be strengthened. Self-amplifying RNA (saRNA) vaccine technology as well as mRNA technology enable rapid and scalable vaccine production, requiring minimal amounts of RNA per dose. In mice, saRNAs have been ...
Nonviral delivery of self-amplifying RNA vaccines. Proceedings of the National Academy of Sciences of the United States of America, 109(36), 14604-9. Gonçalves, et al (2004). The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes. Biophysical Journal, 86(3),...