This approach may enable a quicker response to emerging disease outbreaks, as is evident from the swift pursuit of RNA vaccine candidates for the global SARS-CoV-2 pandemic. Both conventional and self-amplifying RNAs have shown protective immunization in preclinical studies against multiple infectious ...
RNA vaccine candidates for the global SARS-CoV-2 pandemic. Both conventional and self-amplifying RNAs have shown protective immunization in preclinical studies against multiple infectious diseases including influenza, RSV, Rabies, Ebola, and HIV-1. Self-amplifying RNAs have shown enhanced antigen ...
Self-amplifying RNA (saRNA) is an extremely promising platform because it can produce more protein for less RNA. We used a sort and sequence approach to identify host cell factors associated with transgene expression from saRNA; the hypothesis was that cells with different expression levels would ...
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability npj Vaccines, 7 (2022), p. 136, 10.1038/s41541-022-00549-y View in ScopusGoogle Scholar [116] S.A. Dilliard, D.J. Siegwart Passive, active and endogenous organ-targeted lipid and polymer nanoparticles...
Rapid response to emerging diseases is critical when developing a vaccine. Long RNA (mRNA and saRNA) is at the forefront of vaccine development. Benefits of saRNA saRNA vaccines can be developed in a fraction of the time it takes to develop a conventional vaccine ...
The technology usesgenetic codecalled self-amplifying RNA (saRNA). This genetic information holds instructions to make a protein found on the outside of the coronavirus, called the spike protein. Once injected into the muscle of the arm, the cells make this spike protein, enabling the immune sy...
AstraZeneca has entered a strategic, long-term research collaboration with biopharmaceutical firm VaxEquity to discover, develop and commercialise self-amplifying RNA (saRNA) therapeutics platform. AstraZeneca Cambridge Biomedical Campus in Cambridge, England. Credit: AstraZeneca. Subscribe to our email...
Self-amplifying mRNA (samRNA) is rapidly emerging as a well-tolerated, scalable and widely-applicable platform technology which can be used to develop multiple vaccines simply by changing the sequence of the antigen (the target o...
Self-amplifying messenger ribonucleic acid (saRNA) provides extended expression of genes of interest by encoding an alphavirus-derived RNA replicase and thus is 2–3 times larger than conventional messenger RNA. However, quality assessment of long RNA transcripts is challenging using standard techniques...
Taken together, these experiments demonstrate that the circular properties of the RNA cause immune gene stimulation. CircRNA Biogenesis Dictates RNA Activation of Immune Signaling Next, we mapped the feature of circRNA required to activate innate immune gene expression. We used a phage td intron to ...