It references the article "Nonviral delivery of self-amplifying RNA vaccines," by A. Geall and colleagues in the 2012 issue of the "Proceedings of the National Academy of Sciences" (PNAS). Moreover, it was found that injection of mRNA or plasmid DNA (pDNA) into a mice's skeletal ...
Self-amplifying RNA (saRNA) Revolutionizing Vaccine Development Rapid response to emerging diseases is critical when developing a vaccine. Long RNA (mRNA and saRNA) is at the forefront of vaccine development. Benefits of saRNA saRNA vaccines can be developed in a fraction of the time it takes to...
Self-amplifying RNA vaccines for infectious diseasesdoi:10.1038/S41434-020-00204-YKristie BloomFiona van den BergPatrick ArbuthnotNature Publishing Group
More information:Katrina M. Pollock et al, Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against COVID-19: COVAC1, a Phase I, Dose-Ranging Trial,SSRN Electronic Journal(2021).
Several RNA viruses possess a genomic RNA replicon, providing a property of RNA self-amplification [1]. In this context, self-amplifying RNA (saRNA) viruses with a single-stranded RNA of positive polarity comprise of alphaviruses and flaviviruses, while measles viruses and rhabdoviruses carrying a...
“Due to increased antigen levels, one injection of saRNA—whether linear or circular—may cause adverse events comparable with repeated (booster) injections of modRNA.” Mr. Steger had previously pointed out thatBioNTech’s “mRNA” vaccines are made not with mess...
RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa...
Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, circular RNA, antisense RNA, self-amplifying RNA, DNA, and gene editing therapeutics. Arcturus...
摘要: Intraperitoneal route enables broader biodistribution and higher saRNA expression.LNPs excel in RNA delivery efficiency but induce significant inflammation.Higher RNA transfection does not always correlate with higher protein expression.Reactogenicity is modulated by biodistribution....
RDRP, RNA-dependent RNA polymerase; GOI, gene of interest; saRNA, self-amplifying RNA. After the delivery to the host cells, saRNA as well as the double-stranded RNA intermediates produced during the self-replication [36] stimulate an innate immune system as they are recognized as non-self...