Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, Tompkins KR, Walsh EE, Frenck R, Falsey AR, Dormitzer PR, Gruber WC, Şahin U, Jansen KU. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. Nature. 2020
the smallpox virus has been completely eradicated and the incidence of polio, measles and other childhood diseases has been drastically reduced around the world2. Conventional vaccine approaches, such as live attenuated and inactivated pathogens and subunit vaccines, provide...
Researchers have been experimenting with mRNA for decades as a potential weapon against cancer, but they haven't had much luck -- until now. In a new study, scientists tested two groups of melanoma patients. They found nearly 79% of patients had no recurrence after 18 months when given a ...
Türeci Ö, Thompkins KR, Lyke KE, Raabe V, Dormitzer PR, Jansen KU, Sahin U, Gruber WC. RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study. medRxiv [Preprint]. 2020 Aug 20:2020.08
67、 Kubler, H. et al. Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study. J. Immunother. Cancer 3, 26 (2015). 68、 Rausch, S., Schwentner, C., Stenzl, A. & Bedke, J. mRNA vaccine CV9103 and CV9104 for the treatment of ...
ANNOUNCES FIRST PARTICIPANT DOSED IN PHASE 1 STUDY OF ITS MRNA EPSTEIN-BARR VIRUS (EBV) VACCINE. Retrieved January 5, 2022, from https://investors.modernatx.com/news/news-details/2022/Moderna-Announces-First-Participant-Dosed-in-Phase-1-Study-of-its-mRNA-Epstein-Barr-Virus-EBV-Vaccine/...
The mRNA vaccine emerges as a powerful and general tool against new viral infections, largely due to its versatility and rapid development. In addition to prophylactic vaccines, mRNA technology also offers great promise for new applications as a versatile drug modality. However, realizing the ...
F, Yang D, et al. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine ...
最初,DNA疫苗(DNA vaccine)被认为比mRNA疫苗(mRNA vaccine)更有前景,因为DNA更稳定。然而,由于进展缓慢,早期在小型动物中DNA疫苗令人鼓舞的结果并未在人中重现[5]。一个可能的原因是,注射的DNA必须穿过两个屏障,即质膜和核膜,到达转录(transcription,DNA转换成mRNA)发生的细胞分区。相反,mRNA疫苗只需要进入细胞质,在...
[8] Corbett,K.S.,Edwards,D.K.,Leist, S.R. et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 586,567–571 (2020).doi:10.1038/s41586-020-2622-0 [9] Mulligan,M.J.,Lyke, K.E....