This yielded a wide variety of VH/VL orientations relative to the Env epitope (Supplementary Fig. 2A). Four antibody residues form the N332-glycan interaction interface: heavy chain residues D115 and light chain residues Y48, Y51, and S58 (Supplementary Fig. 2B). Of the four hundred ...
The R2lox proteins that have been structurally characterized to date were shown to contain a Mn/Fe heterodinuclear metallo-cofactor, similar to R2c enzymes, coordinated by four glutamate and two histidine residues, however they are not involved in ribonucleotide reduction [4, 22]. In contrast to...