SARS-CoV-2: structure, host, virus source and pathogenesisMingxue LiYueying YangYang LiuMengzhu ZhengDejuan SunHua LiLixia ChenAsian Journal of Traditional Medicines
Size of SARS-CoV-2 genome is 30 kb. One third of this genome is responsible for encoding the structural proteins of the virus, and the rest of the genome shows expression and replication [18]. Structure of this virus consists of membrane glycoproteins (M), spike proteins (S), ...
研究发现,SARS-CoV-2的S蛋白中有一个“弗林蛋白酶样切割位点”(FCS),可以解释该病毒的高致病性。 组织蛋白酶L/Cathepsin L 通过裂解蛋白酶激活SARS-CoV-2的S蛋白是病毒感染的关键步骤。不同的溶酶体组织蛋白酶与通过胞吞作用进入人类冠状病毒有关。有研究表明仅组织蛋白酶L参与了SARS-CoV-2内吞作用。 衔接蛋白...
Virus18. The filaments had a uniform average diameter of 2.68 nm (SD = 0.23 nm,n = 80 from two tomograms) (Fig.1f), which corresponds well to the diameter of the A-form RNA double-stranded helix19and is in accord with anti-dsRNA immuno-EM SARS-CoV-1 studies10. We...
The SARS-CoV-2 is a single stranded positive RNA virus of ~ 29.9 kB in size. The SARS-CoV-2 has 14 open reading frames (ORFs), which encodes for 27 different proteins [55]. It has 5′ untranslated region (UTR), replication complex (ORF1a and ORF1b), Spike (S) gene, Envelope...
SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA ...
This survey presents basic information on the structure and replication cycle of SARS-CoV-2. Fundamental discoveries in the genetics and molecular biology of the virus paved the way to design and development of molecules that would act as potential therapeutic agents for COVID-19.The virus belongs...
相关研究结果于2020年4月10日在线发表在Science期刊上,论文标题为“Structure of the RNA-dependent RNA polymerase from COVID-19 virus”。 细菌表达的全长SARS-CoV-2 nsp12(残基S1-Q932)与nsp7(残基S1-Q83)和nsp8(残基A1-Q198...
we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor ACE2. The overall ACE2-binding mode of the SARS-CoV-2 RBD is nearly identical to that of the SARS-CoV RBD, which also uses ACE2 as the cell recepto...
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581, 215–220 (2020). CAS PubMed Google Scholar Blanco-Melo, D. et al. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell 181, 1036–1045.e9 (2020). CAS PubMed ...