Late December 2019, a new virus outbreak was detected in Wuhan, Hubei province China and later spread all over the world. The virus is a new strain of the 尾 - Coronavirus (SARS - CoV - 2) with a single strand positive sense RNA, and a genome size of 29,890 kb that codes for ...
多克隆血清抗体以及目前大多数发展用于治疗SARS-CoV-2的抗体,其靶点是与ACE2接触面重叠的受体结合区(RBM, Receptor binding motif),而SARS-CoV-2的很多亚型和其他的Sarbecovirus之间的RBM存在明显的遗传差异性,因此这些抗体的广谱性受...
Sarbecovirus(包含SARS-CoV-2, SARS-CoV等病毒,又称:类SARS冠状病毒或沙贝病毒)编码了一套独特的辅助蛋白(accessory proteins),与病毒在细胞中的生存、适应以及天然免疫逃逸密切相关。例如,SARS-CoV-2辅助蛋白ORF9b和ORF6均属于抗病毒天然免疫应答的抑制因子。 当前,“受关注的SARS-CoV-2变种病毒”VOCs不断涌现,...
Increasing evidence accumulated from the past year on the outbreak of corona virus disease 2019 (COVID-19) pandemic, suggesting a strong association between the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection and autoimmunity. The reported inflammatory/autoimmune-related symptoms...
Sarbecovirus(包含SARS-CoV-2, SARS-CoV等病毒,又称:类SARS冠状病毒或沙贝病毒)编码了一套独特的辅助蛋白(accessory proteins),与病毒在细胞中的生存、适应以及天然免疫逃逸密切相关。例如,SARS-CoV-2辅助蛋白ORF9b和ORF6均属于抗病毒天然免疫应答的抑制因子。当前
Correlation of pre-existing comorbidities with disease severity in individuals infected with SARS-COV-2 virus Shortly after the first publication on the new disease called Coronavirus Disease 2019 (Covid-19), studies on the causal consequences of this disease began......
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health prob...
理解广谱中和性sarbecovirus抗体反应是开发新型疗法针对SARS-CoV-2突变体即未来人畜共患sarbecovirus病毒的关键。近日,一篇发表在国际杂志Science上题为“Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry”的...
SARS-CoV-2 vaccines, where do we stand? Alain Fischer - 《Comptes Rendus Biologies》 - 2021 - 被引量: 0 564. SARS-CoV-2 Ferritin Nanoparticle Vaccines Elicit Broad SARS Coronavirus Immunogenicity Joyce M G,Chen Wei-Hun...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern worldwide. Notably, co-infection with other pathogens may worsen the severity of COVID-19 symptoms and