First encounter with SARS-CoV-2: immune portraits of COVID susceptibility Controlled infection with SARS-CoV-2 of people who hadn’t previously been exposed to the virus reveals how molecular and cellular signa
Understanding the interactions between viral proteins and components of human cells is essential for elucidating their pathogenic mechanisms and for development of effective therapeutic agents. Because SARS-CoV-2 is an RNA virus, and many of its encoded proteins are known to bind RNA (Sola et al....
We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S1/S2 subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain ...
由于SARS-CoV-1和SARS-CoV-2之间的高度同源性,它们共享一些抗原区域。类似地,MERS-CoV和SARS-CoV-2在S糖蛋白上有35%的同源性(32)。最重要的是,来自SARS-CoV-1和SARS-CoV-2的S糖蛋白的RBD具有高度同源性,并且两者都参与与ACE2...
SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19).Latest Research and Reviews Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base Here the authors ch...
CoV SUD is absent in SARS-CoV-2 SUD. Incorporating this bond in SARS-CoV-2 SUD allowed crystal structure determination to 1.35 Å resolution. However, introducing this bond in SARS-CoV-2 genome was lethal for the ...
Protein Structure Protein function predictions Selenium-binding proteins Structural Biology Structural Variation Viral proteins Introduction Novel coronavirus, also termed Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2), the causative agent of Corona virus disease (COVID-19), continuously imposes ...
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SARS-CoV-2: from its discovery to genome structure, transcription, and replication Abstract SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA...
SARS-Cov-2 began to spread in Wuhan in December 2019. The epidemic has swept the country. The population is generally susceptible because the population lacks immunity to the new virus strains. SlR model is a commonly used infectious disease model. Using this model to analyze the development tr...