SARS-CoV-2首次从一个在武汉华南海鲜市场工作的感染者支气管肺泡灌洗液中利用宏基因组测序拼接出来,系统发育分析首次发现该病毒和蝙蝠来源的SARS样冠状病毒(SARS-like CoV)紧密聚在β冠状病毒属,Sarbecovirus亚属[21],由此开启病毒溯源系列研究。 在这之后,有研究者将公布的新型冠状病毒序列与不同来源的冠状病毒序列...
1.严重急性呼吸综合征冠状病毒2或“sars-cov-2”是一种引起冠状病毒病(covid-19)的病毒株。参见例如戈尔巴伦尼亚(gorbalenya)ae等人,自然微生物学(nature microbiology).5(4):536-544(2020年3月)。需要进行治疗性处理来解决全球大流行病。 附图说明 2.图1a和1b描绘了阻断sars-cov2病毒(“sc2病毒”)进入的...
由于SARS-CoV-1和SARS-CoV-2之间的高度同源性,它们共享一些抗原区域。类似地,MERS-CoV和SARS-CoV-2在S糖蛋白上有35%的同源性(32)。最重要的是,来自SARS-CoV-1和SARS-CoV-2的S糖蛋白的RBD具有高度同源性,并且两者都参与与ACE2...
Cryo-electron microscopy (cryo-EM) studies of SARS-CoV-1 and the closely related murine hepatitis virus (MHV) show that the virions are predominantly spherical or ellipsoidal with an average envelope diameter between 80 and 90 nm3. The main structural components of coronaviruses are the glycopr...
in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution. Introduction Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Wuhan, China, in December 2019, the virus has spread across the globe and has caused over 70 million ...
In this study, we present the crystal structure of the C-terminal domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (hACE2), which reveals a hACE2-binding mode similar overall to that observed for SARS-CoV. However, atomic details at the binding ...
SARS-CoV-2: from its discovery to genome structure, transcription, and replication Abstract SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA...
7月 6 日,中国医学科学院病原生物学研究所崔胜课题组与香港大学微生物学系袁硕峰课题组合作在学术期刊Nature Communications上发表了题为“Identification of the SARS-unique domain of SARS-CoV-2 as an antiviral target”的论文。他们首先解析了 SARS-CoV-2 的 SARS 独特结构域(SUD)的高分辨率结构,发现 SARS...
CoV SUD is absent in SARS-CoV-2 SUD. Incorporating this bond in SARS-CoV-2 SUD allowed crystal structure determination to 1.35 Å resolution. However, introducing this bond in SARS-CoV-2 genome was lethal for the ...
Fig. 1. Genome organization, protein function, and structure of SARS-CoV-2. (A) Genome organization and protein function of SARS-CoV-2. ORF1a and 1b at the 5ʹ untranslated region are coding for polyproteins (pp1a/ab) cleaved in several nonstructural proteins (nsps) required for virus...