SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19). Latest Research and Reviews Distal protein-protein interactions contribute to nirmatrelvir resistance ...
Compared to other age groups, COVID-19 is less common in children and infection is mainly asymptomatic. It has been reported that around 86% of COVID‐19 infected children in China remained undiagnosed which may constitute a risk for infection in elderly people [22]. Therefore, a small numbe...
Interferon (IFN)-mediated antiviral pathway is one of the major innate immune mechanisms against invading viral pathogens, which consists of two stages including IFN activation and IFN signaling. In the former one, viral infection rapidly induces expression and secretion of type I and III IFNs. In...
SARS-CoV-2 is single strand RNA virus which uses type 1 transmembrane spike (S) glycoprotein projections as a lock-and-key combination to breach cells. The viral glycosylated cell surface protein can be further classified as using two (S1 and S2) functional domains which manage the entry proce...
Clinically, patients with COVID-19 present with severe respiratory distress syndrome, which is very similar to the presentation of other respiratory viral infections. A huge variation in the host response exists, with the resulting symptoms varying from mild to moderate. Comorbidities such as ...
ACE2 is a key component of the renin-angiotensin system (RAS), which plays an essential role in the homeostatic regulation of blood pressure, electrolyte, and fluid balance, as well as in the regulation of vital organ function by the renal and cardiovascular system [33]. ...
The chief reason for its global spread is their associated mutations that are linked to the spike protein, crucial for the attachment and virus entry in host cells via ACE2 [9]. According to GISAID, three main SARS-CoV-2 clades have been found so far, which are clade G (a variant of...
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types. Some factors that can affect the expression of the ACE2 are: sex, envi
SARS-CoV-2 is a coronavirus belonging to the genus of beta coronavirus, which is enveloped with round or oval particles, often polymorphic, and having a diameter ranging from 60 to 140 nm5. The SARS-CoV-2 gene profile significantly differs from that of SARS-CoV and MERS-CoV4. SARS-CoV-...
A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hu...