SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant genetic shift from different isolates. Afte...
SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19). Latest Research and Reviews Distal protein-protein interactions contribute to nirmatrelvir resistance ...
The transmission cycle of SARS-CoV-2. The SARS-CoV-2 originated from bats and pangolins are presumed to be their intermediate amplifying hosts. The virus transmits from animal-to-human to human-to-human. The infected person transmits the virus through cough and sneeze. In the population, the...
Full genome sequences are increasingly used to track the geographic spread and transmission dynamics of viral pathogens. Here, with a focus on Israel, we sequence 212 SARS-CoV-2 sequences and use them to perform a comprehensive analysis to trace the origins and spread of the virus. We find ...
The SARS-CoV-2 spike protein engages angiotensin-converting enzyme 2 (ACE2) on the surface of human cells to facilitate entry and infection of cells6. Upon cell attachment, spike proteins are cleaved by host proteases into S1 and S2 fragments. The S1 protein includes the amino-terminal (NTD...
The immunity conferred by SARS-CoV-2 vaccines and infections reduces the transmission of the virus. To answer how the effect of immunity is shared between a reduction of infectiousness and an increased protection against infection, we examined >50,000
Virus18. The filaments had a uniform average diameter of 2.68 nm (SD = 0.23 nm,n = 80 from two tomograms) (Fig.1f), which corresponds well to the diameter of the A-form RNA double-stranded helix19and is in accord with anti-dsRNA immuno-EM SARS-CoV-1 studies10. We...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop a mild to moderate disease with virus replication restricted mainly to the upper airways, some progress to having a life-threatening...
Full size image SARS-CoV-2 viral loads and mortality risk Eleven participants died, all with respiratory failure listed as the primary cause of death (Supplementary Table2). Compared to individuals who were discharged from the hospital, those who eventually died had significantly higher levels of ...
SARS-CoV-2vaccineIn November 2019, the highly infectious coronavirus SARS-CoV-2 emerged in Wuhan, China, and has since spread to almost all countries worldwide. Since its emergence, the COVID-19 infection has led to significant public health, economic and social problems. The current pandemic ...