尽管SARS-CoV-2在体内广泛分布,但我们观察到肺外缺乏炎症或直接病毒细胞病理学。我们的数据证明,SARS-CoV-2会导致全身感染,并能在体内持续数月。 作为一种RNA病毒,SARS-CoV-2进入宿主细胞复制基因组RNA并产生许多较小的RNA,称为亚基因组RNA(subgenomic RNA,sgRNA)。本文通过qRT-PCR检测病毒的sgRNA提示了最近复制的...
Most of the mutations that occur in the SARS-CoV-2 genome have no notable effect on the spread and the virulence of the virus, and hence on the course of the disease [2]. The greatest concern about such emerging mutations is a risky change that could lead to an increase in the ...
The type I interferon (IFN-I) immune signaling has been found to be dampened in COVID-19 cases, raising the hypothesis that SARS-CoV-2 uses some mechanism(s) to evade IFN-I-mediated antiviral innate immunity, which contributes to the pathogenicity of SARS-CoV-2. Indeed, during coevolution...
To assess the predictability of post-COVID after mild initial disease, we use machine learning methods and find that pre-infection characteristics, combined with information on the SARS-CoV-2 virus type and vaccine status, to a considerable extent (AUC = 0.79, 95% CI 0.75–0.81) could ...
2020年3月6日, virological网站上传了MRC-University of Glasgow Centre for Virus Research的David L. Robertson团队的一篇文章,标题为“Response to “On the origin and continuing evolution of SARS-CoV-2” ,作者针对此前3月3日发表在National Science Review上的“On the origin and continuing evolution of ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense RNA coronavirus responsible for the COVID-19 pandemic. Since December 2019, coronavirus disease 2019 (COVID-19) has affected more than 127 million people, 2.7 mi
我们发现SARS-CoV-2是广泛分布的,尤其是在死于严重新冠肺炎的患者中,病毒复制存在于感染早期的多个呼吸道和非呼吸道组织中,包括大脑。此外,我们在多个解剖部位(包括整个大脑)检测到持续存在的SARS-CoV-2 RNA,最迟在一例患者出现症状后230天。尽管SARS-CoV-2 RNA在全身广泛分布,但我们几乎没有观察到呼吸道之外的...
Similar to SARS-CoV, the identified pathogen of the 2002-2003 outbreak, SARS-CoV-2 is a ~30-kb positive single-stranded RNA virus. Genome organization of SARS-CoV-2 is similar to that of SARS-CoV, with both being organized into two main open reading frames (ORFs) and several smaller ...
SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19). Latest Research and Reviews Distal protein-protein interactions contribute to nirmatrelvir resistance ...
研究SARS-CoV-2致病机制对于SARS-CoV-2防控具有重要意义。天然免疫反应是宿主抵御病毒感染的第一道防线,通常由识别病原体相关分子模式启动。许多SARS-CoV-2病毒蛋白可以拮抗IFN-I反应,比如nsp3蛋白、nsp12蛋白、nsp14蛋白、ORF6、ORF9b、ORF10等蛋白。细胞自噬能促进SARS-CoV-2复制,SARS-CoV-2能诱导不完全细胞...