The SARS-CoV-2 genome is a non-segmented large positive-sense stranded RNA with a length of about 30 kb. It contains a 5′-cap structure and a 3′-poly-A tail [7,9]. The viral genome encodes 29 proteins, including 25 putative non-structural and accessory proteins and four structural...
Structure of SARS-CoV-2 virionThe structure and main physicochemical characteristics of the SARS-CoV-2 virion with the spike transmembrane protein corona were discussed. Using these data, diffusion coefficients of the virion in aqueous media and in air were calculated. The structure and dimensions ...
先前的研究也揭示了位于 SARS-CoV-2 RBD 上的保守表位的存在。因此,去鉴定和靶向 SARS-CoV-2 变体中高度保守的表位看来是很可行的,对于设计广泛中和抗体和疫苗可能很重要。 在这篇文章中,作者团队设计了一种双特异性抗体,而且可以通过吸入式有效地输送到肺部,并在 SARS-CoV-2 感染的小鼠模型中表现出优异的疗效...
Virion assembly and structure of intracellular virions The ERGIC constitutes the main assembly site of coronaviruses13and budding events have been described by EM studies10,23,24. In situ cryo-ET allowed us here to study SARS-CoV-2 virion assembly in close to native conditions and enabled us ...
Size of SARS-CoV-2 genome is 30 kb. One third of this genome is responsible for encoding the structural proteins of the virus, and the rest of the genome shows expression and replication [18]. Structure of this virus consists of membrane glycoproteins (M), spike proteins (S), ...
SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and facilitate structure-based drug development, we develop a virion RNA ...
SARS-CoV-2 genome structure and expression Like other hCoVs, SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of 29,882 [31], 29,891 [4] or 29,903 nucleotides (nts) [5]. The genome is packed by viral nucleocapsid (N) proteins as a large ribonucleoprotein (RNP)...
Top mutations in SARS-CoV-2 in different geographic areas The mutation is the engine of evolution that generates genetic diversity. It has been demonstrated that mutations in the SARS-CoV-2 genome are responsible for a drastic change in the protein structure and lead to an increase in the infe...
Origin and Structure of SARS-CoV2 A sample isolation from pneumonia patients who were some of the workers in the Wuhan seafood market found that strains of SARS-CoV-2 had a length of 29.9 kb [8]. Structurally, SARS-CoV-2 has four main ...
The SARS-CoV-2 is a lipid-enveloped, single-stranded, and positive-sense RNA (+ ssRNA) virus with a large genome length of 29,903 nucleotides that contains a 5′-cap structure, a 3′ poly(A) tail, 2 flanking untranslated regions (UTRs), and multiple open reading frames (ORFs) whic...