Figure 1. Workflow for TaqMan SARS-CoV-2 Mutation Panel[Click to enlarge] For Research Use Only. Not for use in diagnostic procedures. Performance Our menu of verified real-time PCR research assays provide robust detection of SARS-CoV-2 mutations. Bel...
基于此,团队对Jun12682进行了体内药效研究,结果显示,对SARS-CoV-2感染BALB/c小鼠,Jun12682口服给药不仅显著提高小鼠存活率,而且能够显著降低小鼠肺部病毒滴度和组织损伤,且降低多种炎症因子的表达(图2)。 图2 PLpro 抑制剂Jun12682的共晶结构和小鼠抗...
SARS-CoV-2刺突蛋白的亚基 S1 被认为是一个突变热点,可能在毒性、传播能力和宿主免疫逃逸方面具有很高的临床相关性,其他突变也可能导致病毒对抗 SARS-CoV-2 的抗体抵抗力增强[3,4]。 图2 SARS-CoV-2 病毒突变的影响[3,4] 图片来源:根据论文原图改编(侵删) 02大家常说的 VOC/VOI 是什么,有哪些重要的突变...
A variant is a group of coronaviruses that share the same lineage of mutation. If enough mutations accumulate in a lineage, it might change the way the variant functions. These lineages are known as strains. Consequently, COVID-19 is caused by a coronavirus strain known as SARS-C...
mutation hotspotSARS‐CoV‐2virus bioinformaticsThe ongoing pandemic caused by a novel coronavirus, SARS-CoV-2, affects thousands of people every day worldwide. Hence, drugs and vaccines effective against all variants of SARS-CoV-2 are crucial today. Viral genome mutations are commonly existent ...
标题(英文):Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies 标题(中文):剖析从病毒泛基因组到单个感染类群的 SARS-CoV-2 变异指纹图谱 发表期刊:Genome Medicine 作者单位:斯坦福大学医学院等 发表年份:2021 文章地址:doi.org/10.1186/s13073-...
Through the first mechanism, the SARS-CoV-2 genome experiences random errors during replication, most of which are corrected or "proof-read" successfully, so these mutations are normally of little or no consequence. "The mutation rate of SARS-CoV-2 RNA viruses, naturally, can be very lo...
SARS-CoV-2是一种β型冠状病毒，可导致呼吸道感染，严重者会出现死亡【1】。疫苗作为重要的防治手段，大大缓解了COVID-19大流行带来的危害，但自Omicron和 Delta等多种变异病毒的出现，致使疫苗的有效性显著下降，这也促使科学家寻找新的治疗手段来解决变异病毒的耐药性问题。至今为止，FDA已批准三种抗病毒药物，...
由于RNA依赖性RNA聚合酶产生的错误,SARS-CoV-2的基因组在病毒复制过程中容易受到突变的影响。这些突变使SARS-CoV-2能够进化成新的毒株。病毒准物种来自个体患者发生的新发突变。结合这些病毒突变集,提供了独特的遗传指纹,揭示了传播模式,并在接触者追踪中具有实用性。
9. SaitoA, Nasser H, Uriu K, Kosugi Y, Irie T, Shirakawa K, et al. SARS-CoV-2spike P681R mutation enhances and accelerates viral fusion. bioRxiv.2021:2021.06.17.448820. doi: 10.1101/2021.06.17.448820. 10. WallEC, Wu M, Harvey R, Kelly G, Warchal S, Sawyer C, et al. Neutralisi...