SARS-CoV-2 Antibodies:SARS-CoV2 specific antibodies could cross-react with SARS-CoV-2 proteins, mainly the Spike, but also the envelope, membrane and nucleocapsid proteins, and SARS-CoV-2 induced antisera could cross-neutralize SARS-CoV-2, suggesting the potential to develop SARS-CoV-2 proteins...
The introduction and recent occurrence of VOCs with substantial alterations in the receptor binding site of spike protein (K417 N, K417T, L452R, T478K, E484K, S494P, N501Y) are of particular importance. Specifically, VOC B.1.617.2/Delta has surpassed all prior VOCs in Bangladesh, posing...
Several mutations have been reported in the SARS-CoV-2 genome [113,114,115]. The viral spike protein G614 mutant is the most common and pathogenic mutation of SARS-CoV-2 [116]. Most of the G614 SARS-CoV-2 mutants belong to the G clade and patients infected with this mutant show high...
is not involved in binding25. Mutation K417R had previously been shown to strengthen salt-bridge interactions in the ACE-2-RBD binding complex as well as RBD-RBD interactions within the trimer of a related Pangolin-CoV25,26,27. Moreover, Y453F that was associated with outbreaks in mink f...
2019年起源于中国武汉省的冠状病毒19型疾病(COVID-19)是由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的,其在人类中的感染可导致轻微或严重的临床表现,主要影响呼吸系统。
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC
We further elucidate that the stabilizing effect of N501Y mutation on ACE2 occurs through ACE2-K353 interaction (Fig. 1g, i). Here, the measurement of the inter-atomic distance between the phenolic side chains of Y501 (RBD) and Y41 (ACE2) indicated a possiblepi-piinteraction (distance <...
L452R突变有助于病毒逃避中和抗体识别。结构分析表明L452与E484均位于与中和抗体P2B-2F6的直接接触界面,未突变的L452通过疏水相互作用与抗体重链的I103和V105的氨基酸侧链形成疏水相互作用,同时E484与抗体轻链的N33和Y34建立盐桥和氢键。然而当L452发生R突变后,其精氨酸侧链破坏了原本L452与抗体之间的疏水相互作用...
B.1.617.2, GISAID: EPI_ISL_1534938) included ten reported mutations in the spike (T19R, G142D, del156-157, R158G, A222V, L452R, T478K, D614G, P681R and D950N). The delta plus variant (Pango lineage AY.x, GISAID: EPI_ISL_ 3019629) had one more mutation, K417N, than ...
(Fig.4d, hand Supplementary Fig.6). The results showed that the percentage of the RBD K417N mutant-binding dACE2-positive BHK21 cells was significantly lower than that of the wt RBD-binding dACE2-positive cells. However, the percentage of the RBD N501Y mutant-binding dACE2-positive BHK...