3. Mutations in the spike (S) protein 4. Some SARS-COV-2 variants recently associated with rapid spread 5. Emergence and observation of CoV viral variants by country 6. What the future holds 7. Discussion Contributors’ statement Funding statement Compliance with ethical standards Consent to part...
Staying ahead of mutations may come down to a simple understanding of lineage, and which viral family they belong to.
SARS-CoV-2 mutations and their viral variants. Cytokine Growth F. R. https://doi.org/10.1016/j.cytogfr.2021.06.001 (2021). Article Google Scholar Esteban, D. Chapter 2 - Molecular basis of genetic variation of viruses: error-prone replication. in (eds. Domingo & Esteban) 35–71 (...
beginning with the first mutated G614D variant and culminating in the newly emerged recombinant SARS-CoV-2 and its sub-variants. This review explores the implications of these mutations concerning viral transmission, infectivity, COVID-19 severity, the effectiveness of human neutralizing...
The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity. Cell 182, 1284–1294.e1289 (2020). CAS PubMed PubMed Central Google Scholar Greaney, A. J. et al. Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a ...
In this direction, neutralizing antibodies (nAbs) against SARS-CoV-2, their preclinical and clinical developmental stages have been discussed. The article exemplifies antibody escapes due to emerging mutations in SARS-CoV-2 variants. The small antiviral molecules resistance by the mutations in RdRp of...
mutations that are shared by at least two variants.Reports usually address these mutations, either alone or in combination, in Spike proteins or Spike-pseudotyped viral particles using structural assays (e.g. cryo-electron microscopy), biochemical assays (e.g. ELISA), or cellular assays (e.g....
I certainly share your questions on whether the mutations in the spike protein of the SARS-Cov-2 virus will confer less efficacy of current vaccines. However, your explanation of "the growing threat of viral variants" does not accommodate all aspects of the expanding knowledge of the SARS-Cov...
Nevertheless, a clear definition of the genetic signatures underlying the circulating variants is still missing. Here, we provide a comprehensive insight into mutational profiles characterizing each SARS-CoV-2 variant, focusing on spike mutations known to modulate viral infectivity and/or antigenicity. ...
SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation Valentino Bezzerri, Valentina Gentili, Martina Api, Alessia Finotti, Chiara Papi, Anna Tamanini, Christian Boni, Elena Baldisseri, Debora Olioso, Martina Duca, Erika Tedesco, ...