SARS-CoV-2 has had many mutations and evolved into six subtypes. • Three SARS-CoV-2 subtypes have significantly strengthened their infectivity. • A few future mutations have high chances to produce more contagious viruses. Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Mutations in SARS-CoV-2 variants of concern (VOCs) have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies (NAbs). How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be investigated. The entry ...
SARS-CoV-2 mutation R203K/G204R infectivity fatality nucleocapsid virulence fitness COVID-19 Sorry, something went wrong. Please try again and make sure cookies are enabled Data and code availability All sequence data used here are available from GISAID (www.gisaid.org) and CoVdb (covdb.popge...
Therefore, we provide direct evidence that naturally occurring mutations in SARS-CoV-2 can substantially change its replication dynamics and infectivity in diverse human cell lines, with clinical implications in vivo.doi:10.1038/s41421-020-00226-1Hangping Yao...
Mutations in SARS-CoV-2 variants of concern(VOCs)have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies(NAbs).How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be investigated.The entry efficiency of ...
Mutations in the spike RBD of SARS-CoV-2 omicron variant may increase infectivity without dramatically altering the efficacy of current multi-dosage vaccinationsdoi:10.1101/2021.12.08.471688Bingrui LiXin LuoKathleen McandrewsRaghu Kalluri
SARS-CoV-2mutationR203K/G204RinfectivityfatalityIn this study, cooccurring mutations R203K/G204R in the nucleocapsid protein are demonstrated adaptive and associated with the emergence of a high-transmissibilWu, HaiboXing, NaMeng, KaiwenFu, Beibei...
Recently, the SARS-CoV-2 variants from the United Kingdom (UK), South Africa, and Brazil have received much attention for their increased infectivity, potentially high virulence, and possible threats to existing vaccines and antibody therapies. The question remains if there are other more infectious...
Archives of Virology - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a major impact on global human health. During the spread of SARS-CoV-2, weakened host immunity and the...doi:10.1007/s00705-021-05327-0Springer ViennaArchives of Virology...
SARS-CoV-2Background:Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron. N501Y in the receptor-binding domain (RBD) of Spike protein is the key mutation dictating the mouse infectivity,...