The biological role of telomeres is to prevent shortening of DNA to preserve integrity of the genome. Length of telomeres is determined by age, sex, and environmental exposures. Telomeres are vulnerable to injury by oxidative stress. Telomere length is sustained by telomerase, a ribonucleoprotein ...
Telomeres are specialized genomic structures that protect chromosomal ends to maintain genomic stability. Telomeric length is primarily regulated by the telomerase complex, essentially consisting of an RNA template (TERC), an enzymatic subunit (telomerase reverse transcriptase, TERT). In humans, telomerase...
Solomon, et al.The role of telomeres and telomerase in the pathology of human cancer and aging. The Journal of Pathology . 2006Shin, J. S.; Hong, A.; Solomon, M. J.; Lee, C. S. The role of te- lomeres and telomerase in the pathology of human cancer and ag- ing. Pathology, ...
Blackburn EH (1991) Structure and function of telomeres. Nature 350:569–573 Article PubMed CAS Google Scholar Hackett JA, Feldser DM, Greider CW (2001) Telomere dysfunction increases mutation rate and genomic instability. Cell 106:275–286 Article PubMed CAS Google Scholar Allsopp RC, Chang...
Solomon, et al.The role of telomeres and telomerase in the pathology of human cancer and aging. The Journal of Pathology . 2006Shin JS,Hong A,Solomon MJ,et al.The role of telomeres and telomerase in the pathology of human cancer and aging.Pa-thology. 2006...
The first report of the presence of alternative lengthening of telomeres (ALT) in cancers arising from the bladder, cervix, endometrium, esophagus, gallbladder, liver, and lung was published today in The American Journal of Pathology. The presence of ALT
Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are...
Cellular senescence, the state of permanent growth arrest, is the inevitable fate of replicating normal somatic cells. Postulated to underlie this finite replicative span is the physiology of telomeres, which constitute the ends of chromosomes. The repetitive sequences of these DNA- protein complexes ...
The telomere鈥搕elomerase hypothesis is the science of cellular aging (senescence) and cancer. The ends of chromosomes, telomeres, count the number of divi... MP Granger,WE Wright,JW Shay - 《Crit Rev Oncol Hematol》 被引量: 313发表: 2002年 Irreparable telomeric DNA damage and persistent DD...
aEssential role of limiting telomeres in the pathogenesis of Werner syndrome. 限制telomeres的根本角色在Werner综合症状发病原理。[translate]