First, short telomeres can play an essential role in stopping the occurrence of cancer. Second, short telomeres can lead to genome instability, which may result in the formation of some cancer cells. However, cancer cell telomeres can be lengthened by the reactivation of telomerase or alternative...
A new mouse model with critically short telomeres has been generated by over-expressing the TRF2 telomere-binding protein, K5-TRF2 mice. These mice show short telomeres in the presence of telomerase activity, leading to premature aging and increased cancer. Short telomeres in TRF2 mice can be ...
Telomeres are specialized genomic structures that protect chromosomal ends to maintain genomic stability. Telomeric length is primarily regulated by the telomerase complex, essentially consisting of an RNA template (TERC), an enzymatic subunit (telomerase reverse transcriptase, TERT). In humans, telomerase...
these telomeres become shorter with each division, potentially resulting in cell death. In some cancers, however, this shortening is counteracted by the ALT mechanism, thus allowing the unlimited growth of thecancer cells.
The role of telomeres and telomerase in the pathology of human cancer and aging. Shin JS,Hong A,Solomon MJ,et al. Pa-thology . 2006Shin;JS;Hong;A;Solomon;MJ;et;al.The role of telomeres and telomerase in the pathology of human cancer and aging.The Journal of Pathology.2006...
Telomeres in cancer and ageing Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG... LE Donate,MA Blasco - 《Philosophical Transactions of the Royal Society B Biological Sciences》 被引量: 246发表:...
Telomeres, telomerase and cancer: an up-date In the mid 1990s, the hypothesis emerged that the upregulation or re-expression of a telomere- synthesising ribonucleoprotein, called telomerase, is a crit... K Dhaene,EV Marck,R Parwaresch - 《Science》...
In healthy cells, telomeres shorten as cells divide. Interruptions in the maintenance of its length may lead to serious disease. Short telomere syndrome can lead to premature aging and death, but long telomeres are associated with cancer. Telomerase protein is responsible for prolonging telomere, ...
Telomeres and telomerase: biochemistry and regulation in senescence and immortalization. One aspect of cancer that has long been known to be central to cancer progression is cellular immortalization and resistance to cell death. Telomerase, which replenishes the DNA at telomeres and protects them, play...
Telomerase acts as an important biomarker for tumor identification, which synthesizes telomeric repeats at the end of chromosomes telomeres during the replicative phase of cell cycle thus the expression level of telomerase changes as cell cycle progression. Although many efforts have been achieved in de...