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This book provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancer. Telomere shortening results in telomere dysfunction, which represents one of the basic aspects of ageing contributing to the accumulation of DNA damage during ageing...
Telomeres,telomerase and cancer:an endless search to target the ends[J].CELL CYCLE,2004,(09):1138-1150.Telomeres, telomerase and cancer: an endless search to target the ends. Satyanarayana A,Manna MP,Rudolph KL. Cell Cycle . 2004Satyanarayana A, Manns MP, Rudolph KL. Telomeres, telomerase...
Role of telomeres and telomerase in cancer. Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was ... SE Artandi,RA Depinho - Semin Cancer Biol 被引量: 982发表: 2010年 Meeting Report: The...
Telomere length may be maintained in cancer cells by telomerase or an alternative lengthening of telomeres (ALT) mechanism. Low levels of telomerase activity have been detected in some normal somatic cells and presumably some types of normal cells also have low levels of an ALT-like activity. It...
A. Telomeres and telomerase in cancer. Carcinogenesis 31, 9–18 (2010). Article CAS PubMed Google Scholar Maciejowski, J., Li, Y., Bosco, N., Campbell, P. J. & de Lange, T. Chromothripsis and kataegis induced by telomere crisis. Cell 163, 1641–1654 (2015). Shows that dicentric ...
Keywords: cancer; aging; senescence; immortality; telomerase; telomeresdoi:10.1038/npg.els.0006067Michel M OuelletteKyung Hyun ChoiAmerican Cancer SocietyCalvin B Harley,Bryant Villeponteau. Telomeres and telomerase in aging and cancer[J].Current Opinion in Genetics and Development,1995,(2):249-255....
Cancer InvestigationHelder,M.N., Wisman,G.B. and van der Zee,G.J. (2002) Telomerase and telomeres: from basic biology to cancer treatment. Cancer Invest., 20, 82-101.Helder MN,Wisman GB,van der Zee GJ.Telomerase and telomeres: from basic biology to cancer treatment. Cancer Investigation...
In 1991 we proposed a connection between telomeres, telomerase, aging and cancer [5]. The hypothesis put forth was that most normal human cells lack telomerase activity and their telomeres shorten with each cell division, until they enter replicative senescence (Fig. 1). Cells that lose critical...
Telomerase is a key enzyme for cell survival that prevents telomere shortening and the subsequent cellular senescence that is observed after many rounds of cell division. In contrast, inactivation of telomerase is observed in most cells of the adult liver. Absence of telomerase activity and ...