Whereas there were many basic research advances presented, the focus of this overview will be the areas of clinical advances.doi:10.1016/j.semcancer.2011.10.001Jerry W. ShayWoodring E. WrightSemin Cancer BiolShay, J.W.; Wright, W.E. Role of telomeres and telomerase in cancer. Semin. ...
Telomerase is a key enzyme for cell survival that prevents telomere shortening and the subsequent cellular senescence that is observed after many rounds of cell division. In contrast, inactivation of telomerase is observed in most cells of the adult liver. Absence of telomerase activity and ...
Shin JS,Hong A,Solomon MJ,et al.The role of telomeres and telomerase in the pathology of human cancer and aging.Pa-thology. 2006Shin, J.S.; Hong, A.; Solomon, M.J.; Lee, C.S. The role of telomeres and telomerase in the pathology of human cancer and aging. Pathology 2006, 38,...
Telomerase is a ribonucleoprotein that maintains telomeres and is essential for cellular immortality and tumour growth. The differential expression of telomerase in cancer cells makes it an attractive therapeutic target. Anti-sense oligonucleotides directed against the RNA template of hTR and small ...
The chromosome ends have protective structures that distinguish them from broken chromosomes, known as telomeres. The function of telomeres, and that of the cellular activity that synthesises them, telomerase, are proposed to be biological determinants in the processes of cancer and aging. In this ...
Extragenomic double-stranded DNA circles in yeast with linear mitochondrial genomes: potential involvement in telomere maintenance Nucleic Acids Res., 28 (22) (2000), pp. 4479-4487 Google Scholar [36] R.R. Reddel Alternative lengthening of telomeres, telomerase, and cancer ...
Patterns of telomere shortening, genomic instability, and telomerase expression in many cancer tissues compared to adjacent normal tissue implicate telomere crisis as a common crucial event in malignant transformation. In order to understand the role of telomere length in cancer etiology, most ...
CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer microenvironment. They produce the extracellular matrix (ECM) constituents that form the structure of the tumor stroma but are also a source of metabolites, growth factors, chem
A new mouse model with critically short telomeres has been generated by over-expressing the TRF2 telomere-binding protein, K5-TRF2 mice. These mice show short telomeres in the presence of telomerase activity, leading to premature aging and increased cancer. Short telomeres in TRF2 mice can be ...
Because of this, telomerase is an attractive target for inhibition in anti-cancer therapy. Telomeres are maintained by telomerase and hTERT interacts with heat shock protein (HSP) chaperones. This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus,...