Cancer cellCancer stem cellTelomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and...
The role of telomeres and telomerase in the pathology of human cancer and aging. Shin JS,Hong A,Solomon MJ,et al. Pa-thology . 2006Shin;JS;Hong;A;Solomon;MJ;et;al.The role of telomeres and telomerase in the pathology of human cancer and aging.The Journal of Pathology.2006...
Telomeres, telomerase and cancer: an up-date In the mid 1990s, the hypothesis emerged that the upregulation or re-expression of a telomere- synthesising ribonucleoprotein, called telomerase, is a crit... K Dhaene,EV Marck,R Parwaresch - 《Science》 被引量: 1345发表: 2000年 Telomerase Activi...
Telomerase in cancer: Clinical applications The biology of telomeres and telomerase has been the subject of intensive investigative effort since it became evident that they play a significant role in... V Urquidi,D Tarin,S Goodison - 《Annals of Medicine》 被引量: 73发表: 1998年 加载更多来源...
Telomeres and telomerase: biochemistry and regulation in senescence and immortalization. One aspect of cancer that has long been known to be central to cancer progression is cellular immortalization and resistance to cell death. Telomerase, which replenishes the DNA at telomeres and protects them, play...
A new mouse model with critically short telomeres has been generated by over-expressing the TRF2 telomere-binding protein, K5-TRF2 mice. These mice show short telomeres in the presence of telomerase activity, leading to premature aging and increased cancer. Short telomeres in TRF2 mice can be ...
However, it is upregulated or reactivated in 80-90% of the primary tumors in humans. The human TERT (hTERT) plays a pivotal role in cellular immortality and tumorigenesis. However, the molecular mechanisms of telomerase functioning in cancer have not been fully understood beyond the telomere ...
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 9: 683–690. Article CAS PubMed Google Scholar Blasco MA, 2005. Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. Embo J 24: 1095–...
complexes located at the ends of chromosomes. During normal cell division, these telomeres become shorter with each division, potentially resulting in cell death. In some cancers, however, this shortening is counteracted by the ALT mechanism, thus allowing the unlimited growth of thecancer cells. ...
and treat melanoma. In healthy cells, telomeres shorten as cells divide. Interruptions in the maintenance of its length may lead to serious disease. Short telomere syndrome can lead to premature aging and death, but long telomeres are associated with cancer. Telomerase protein is responsible for ...