Aging is a stochastic process that occurs after reproductive maturity and results from the increasing molecular disorder that continues to exceed the capacity for repair. Molecular disorder has multiple etiologies including damage by oxygen free radicals, cross-linking, and loss of energy states ...
Aging is a complex process that has been shown to be linked to accumulation of DNA damage. Telomere shortening represents a cell-intrinsic mechanism leading to DNA damage accumulation and activation of DNA damage checkpoints in aging cells. Activation of DNA damage checkpoints in response to telome...
A new mouse model with critically short telomeres has been generated by over-expressing the TRF2 telomere-binding protein, K5-TRF2 mice. These mice show short telomeres in the presence of telomerase activity, leading to premature aging and increased cancer. Short telomeres in TRF2 mice can be ...
Telomeres, the repetitive DNA repeat sequences at the end of linear eukaryotic chromosomes protecting chromosome ends from degradation and illegitimate recombination, play a crucial role in cell fate and aging. Due to the mechanism of replication, telomeres shorten as cells proliferate, which ...
Telomeres play an essential role in maintaining chromosomal integrity in the face of physiological stressors. Although the age-related shortening of TL (te... M Venturelli,G Morgan,A Donato,... - 《Clinical Science》 被引量: 21发表: 2014年 Telomere in Aging and Age-Related Diseases BACKGROU...
The role of telomeres and telomerase in the pathology of human cancer and aging. Shin JS,Hong A,Solomon MJ,et al. Pa-thology . 2006Shin;JS;Hong;A;Solomon;MJ;et;al.The role of telomeres and telomerase in the pathology of human cancer and aging.The Journal of Pathology.2006...
Practically then, telomeres and telomerase may represent plausible prognostic and screening cancer markers. Furthermore, if the argument is extended, with assumptions that telomeric attrition is indeed the basis of cellular senescence and that accumulation of the latter equates to aging at the ...
Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG... LE Donate,MA Blasco - 《European Journal of Cancer》 被引量: 355发表: 2011年 Telomeres in cancer and ageing Telomeres protect the chromosome ...
Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Cologne, Germany Björn Schumacher & Jan H. J. Hoeijmakers Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Univ...
it is discussed the role of the anti-inflammatory cytokine IL-10 and other cytokines that affect aging in a more linear way, such as IL-11, which promotes senescence, and IL-4 and IL-15, which promotes longevity. It is also discussed more specific regulators of aging that are downstream ...