Protein regions that lack a stable secondary or tertiary structure. Genetic disease A disease that is caused by mutations in a gene or a group of genes. Somatic mutations Mutations that occur in somatic cells and, therefore, are not transmitted to the next generation. Mendelian disorders Diseases...
Abdelmohsen K, Gorospe M (2012) RNA-binding protein nucleolin in disease . RNA Biol 9 : 799–808. doi: 10.4161/rna.19718Abdelmohsen K, Gorospe M. RNA-binding protein nucleolin in disease . RNA Biol 2012; 9 : 799–808.Abdelmohsen, K.; Gorospe, M. RNA-binding protein nucleolin in ...
The hnRNP family: insights into their role in health and disease. Hum. Genet. 135, 851–867 (2016). Article CAS PubMed PubMed Central Google Scholar Gladka, M. M. et al. Single-cell sequencing of the healthy and diseased heart reveals cytoskeleton-associated protein 4 as a new ...
RNA-binding proteins in human genetic disease. |核心内容: RNA结合蛋白(RNAbindingProteins,RBPs)是基因表达的关键效应分子,因此它们的功能障碍是许多疾病的根源。 RNA结合蛋白可以识别数百个转录本,并形成广泛的调控网络,帮助维持细胞内环境的稳定。(蛋白质的合成需要mRNA作为模板,还需要相关蛋白作为“生产机器/工厂...
RNA-BindingProteinsSplicingFactorsandDiseaseRNA结合蛋白剪接因子和疾病 系统标签: splicingrnaproteinsbindingdisease剪接 Biomolecules2015,5,893–909;doi:10.3390//biom5020893 OPENACCESS biomolecules ISSN2218-273X .mdpi/journal/biomolecules Article RNA-BindingProteins:SplicingFactorsandDisease AlgerM.Fredericks 1,†...
RNA-binding proteins in Mendelian disease Alfredo Castello, ... Thomas Preiss, in Trends in Genetics, 2013 RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncove...
Nucleolins implication in disease is linked to its ability to associate with target RNAs via its four RNA-binding domains and its arginine/glycin-rich domain. By modulating the post-transcriptional fate of target mRNAs, which typically bear AU-rich and/or G-rich elements, nucleolin has been ...
2023年5月1日,美国罗彻斯特大学RNA中心(RNA Center: From Genome to Therapeutics)和Aab心血管研究所(Aab Cardiovascular Research Institute)的姚鹏博士团队在Nucleic acids research杂志上在线发表题为“RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression”的研究[14...
1. Kim HS, Wu PH, Jang IT: Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature.Int J Mol...
CircRNA调节铁死亡目前研究较多的机制为circRNA可以通过与miRNA或RNA结合蛋白(RNA-binding protein,RBP)结合影响GPX4的表达,从而抑制细胞内脂质过氧化过程。CircRNA还可以通过结合miRNA或RBP影响SLC7A11的表达,进而影响胱氨酸/谷氨酸反向转运体系统。少数...