Key words: plant pathology; RING; E3 ubiquitin ligase; stress resistance; disease resistance 0 引言泛素是一个由 76 个氨基酸残基组成的高度保守的多肽,广泛分布于各类细胞,被泛素标记的蛋白质将被特异性识别,其中多聚泛素化的蛋白将被特异性降解从而调控细胞周期,信号传导,DNA 修复,细胞凋亡等过程。而单泛素...
E3泛素连接酶(ubiquitin ligase enzyme)能识别底物蛋白并将其泛素化,导致底物蛋白通过26S蛋白酶体进行降解,是调节蛋白水平的重要因子.植物E3泛素连接酶在调控激素响应,参与形态建成,抗病防御反应和非生物胁迫响应方面起着重要作用.RING(Really Interesting New Gene 1)家族是含环指结构(RING finger domain)的E3泛素连接...
A RING Finger Protein is a type of E3 ubiquitin ligase that contains a RING finger domain, which is a folded domain consisting of seven cysteine residues and one histidine residue binding two zinc ions. This domain is critical for the transfer of ubiquitin to substrates or to other RING finge...
Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity. This is a preview of subscription content, access via your institution Access options ...
蛋白ringfinger连接结构域拟南芥finger 泛素一蛋白连接酶(E3)—-RING.finger蛋白的研究进展刘辉志,韩世平(河南省植物保护植物检疫站,河南郑州450002)摘要:泛素蛋白酶体途径是真核生物体内重要的蛋白质降解途径,其中,目标蛋白的泛素化过程涉及泛素激活酶El,泛素结合酶E2和泛素一蛋白连接酶E3。泛素一蛋白连接酶E3是目标蛋白...
关键词:植物病理学;RING;E3泛素连接酶;抗逆;抗病中图分类号:S435.111ThefunctionsofRING-typeE3ubiquitinligasefamilyinresponsetoabioticandbioticstressLIDayong(InstituteofBiotechnology,FacultyofAgriculture,ZhejiangUniversity,Hangzhou310058)Abstract:TheRINGfamilyisthelargesttypeofE3ubiquitinligaseswhichisspecifiedbyaRING...
Based on extensive structural analysis it was proposed that RING E3 ligases prime the E2~ubiquitin conjugate (E2~Ub) for catalysis by locking it into a closed conformation, where ubiquitin is folded back onto the E2 exposing the restrained thioester bond to attack by substrate nucleophile. However...
环指蛋白5抗体(E3泛素蛋白连接酶RNF5),Anti-RING5可用于免疫组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC,BIO等,产品经无数次市场验证及客户反馈,质量稳定可靠。 产品别名: E3 ubiquitin protein ligase RNF5; G16; HsRma1; NG2; OTTHUMP00000029107; Protein G16; Ring finger; protein 5; RING5; ...
The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING PROTEIN1 for degradation to modulate the salt stress response and ABA signaling in ... H Zhang,F Cui,Y Wu,... - 《Plant Cell》 被引量: 76发表: 2015年 The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING...
The RING (Really Interesting New Gene) family is the largest type of E3 ubiquitin ligases. RING finger domains bind two zinc ions in a unique cross-brace arrangement through a defined motif of cysteine and histidine residues. This arrangement endows the RING domain with a globular conformation, ...