E3 ubiquitin ligasesMdMIEL1ROSStress toleranceRING-finger-containing E3 ubiquitin ligases play important roles in plant response to biotic and abiotoc stresses. In this study, through homology analysis, a Malus × domestica MYB30-Interacting E3 Ligase 1 gene, MdMIEL1 , was identified and ...
Protein preparation protocols along with analysis of the structural features of known RING finger are also presented. 展开 关键词: Ubiquitin, E3 ubiquitin ligase, RING finger, zinc-coordination, anticancer drugs DOI: 10.2174/138161209789271825
gene targeting demonstrates that TRIM25 is essential not only for RIG-I ubiquitination but also for RIG-I-mediated interferon-β production and antiviral activity in response to RNA virus infection. Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-...
Retinoblastoma-binding protein 6 (RBBP6, also known as P2P-R or PACT) is a 200 kDa protein containing a conserved RING Finger domain, which functions as a negative regulator of tumor suppressors p53 and Rb24. As an E3 ubiquitin ligase, RBBP6 promotes the interaction between p53 and Hdm2...
Most TRIM proteins contain a RING domain, which can confer ubiquitin ligase activity and mark proteins for degradation by the proteasome (Fang et al., 2003). Therefore, expression of all constructs was tested both in the presence or absence of the proteasome inhibitor lactacystin. Show abstract ...
The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING PROTEIN1 for degradation to modulate the salt stress response and ABA signaling in ... H Zhang,F Cui,Y Wu,... - 《Plant Cell》 被引量: 76发表: 2015年 The RING finger ubiquitin E3 ligase SDIR1 targets SDIR1-INTERACTING...
Key words: RING finger protein Abiotic stress Ubiquitin ligase E3 锌指蛋白是通过结合 Zn2+ 作为核心,并与其他 几种特定的氨基酸形成稳定的短的可以自我折叠的 "手指"型多肽结构.根据其结构特点,可以将锌指 蛋白分为 C2H2 型,C8 型,C6 型,RING finger 型, C2HC 型,C2HC5 型,C4 型,C3H 型和 C4...
E3 Ubiquitin-Protein Ligase RING1 (RING1) Antibody供应商 Abbexa产品货号 abx015978产品报价 ￥询价/100ul产品说明书 点击查看购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。产品新闻背景资料 This gene belongs to the RING finger family, members of which enc...
E3 ubiquitin ligase activity in this system, demonstrating for the first time that the E3 activity is an intrinsic function of the Parkin protein and does not require posttranslational modification or association with cellular proteins other than an E2 (human Ubc4 E2 was utilized in this ...
Parkin may abolish its ability to block both tumor cell growth and to ubiquitinate and degrade cyclin E, thus loss-of-function suppressing tumorigenicity. The array-based comparative genomic hybridization revealed that murine double minute 2 (MDM2) overexpression, a RING finger E3 ubiquitin ligase, ...