Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-link...
“master-regulator” of Treg was a critical step in defining Treg as a distinct T cell lineage. However, CD25 and Foxp3 expression may also be induced in T cells that lack suppressive function. Moreover, the localization of Foxp3 to the nucleus prevents its use as a marker for the ...
Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. ...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendoc...
(for review see Jonuleit H, Schmitt E. The regulatoryT cellfamily: distinct subsets and their interrelations. J Immunol 2003;171:6323–6327.) Briefly, T regulatory (Tr)-1 cells as well as T helper (Th)-3 T cells express common T cell markers such as CD4 and are characterized by ...
O. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc. Natl Acad. Sci. USA 106, 19256–19261 (2009). Article CAS PubMed PubMed Central Google Scholar Maloy, K. J. et al. CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent...
Regulatory T cells (Tregs) are an immunosuppressive subpopulation of CD4+ T cells that are endowed with potent suppressive activity and function to limit immune activation and maintain homeostasis. These cells are identified by the hallmark transcription
CD4+CD25+ regulatory T (Tr) cells are critical in regulating the immune response and thereby play an important role in the defense against infection and control of autoimmune diseases. Our previous studies demonstrated the involvement of autoimmune responses in periodontitis. The aim of this study ...
FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of Treg biology. Consequences of defective IL-2 signalling are insufficie
“master-regulator” of Treg was a critical step in defining Treg as a distinct T cell lineage. However, CD25 and Foxp3 expression may also be induced in T cells that lack suppressive function. Moreover, the localization of ...