Immunology Variations in antigen presentation define regulatory T cell formation and activity in vivo UNIVERSITY OF PENNSYLVANIA Andrew J. Caton WeisslerKatherine AnnThe studies presented in this dissertation examine how the formation, differentiation, and activity of Foxp3+ regulatory T (Treg) cells can...
The fourth subtype, exhibiting mesenchymal characteristics, shared cellular identity with multipotent Schwann cell precursors, was induced by RAS activation and was enriched in relapsed disease. Notably, CCND1, an essential gene in NB, was regulated by both mesenchymal and adrenergic regulatory networks ...
Development and regulation of cell-mediated immunity in experimental leishmaniasis. Immunol. Res. 27, 489–498 (2003). 23. Belkaid, Y., Piccirillo, C.A., Mendez, S., Shevach, E.M. & Sacks, D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature ...
Here, we identify specific T cell populations and their detailed receptor profiles in melanomas that are conducive to response in patients with metastatic melanoma treated with anti-PD-1 alone or combined anti-PD-1 and anti-CTLA-4 immunotherapy. The quantification of these immune cell populations ...
Transforming growth factor-beta: An important role in CD4+CD25+ regulatory T cells and immune tolerance TGF-, as TGF- has been demonstrated to induce the expression of Foxp3, which acts as a master regulator for the development and function of Treg ... L Zhang,H Yi,XP Xia,... - 《Au...
of new cell type identity requires the evolution of a unique cell type regulatory signature that includes a cell type-specific core regulatory complex (CoRC) of transcription factors, which defines the identity and coordinated gene expression pattern of the new cell type (Arendt et al., 2016). ...
For this reason, mLV integration sites can be used as functional markers of active regulatory elements. Here, we present a retroviral scanning tool, which allows the genome-wide identification of cell-specific enhancers and promoters. Briefly, the target cell population is transduced with an mLV-...
A conserved regulatory mechanism protects plants against the potentially damaging effects of excessive light. Nearly all photosynthetic eukaryotes are able... K,K,Niyogi,... - 《Plant Cell》 被引量: 1551发表: 1998年 Markers of inflammation and cardiovascular disease: application to clinical and publ...
We used the proximal cis -regulatory element (pCRE) of the retina-specific homeobox gene 2 ( rx2 ) to address such a network. Lineage analysis in the fish retina identified rx2 as marker for multipotent NSCs. rx2 -positive cells located in the peripheral ciliary marginal zone behave as stem...
Significant differences in cell-type abundance were identified with both Wilcoxon testing and a generalized linear model-based method called Milo16, which produced consistent results. For example, regulatory T cells (Tregs) were enriched in polyps relative to unaffected tissue, while naive B, memory ...