Regulatory T cells "CD4+, CD25+" and transcription factor FOXp3+ exert an antagonistic impact on the antitumor strategy developed by the body's immune system during malignancies. Different mechanisms have revealed that these cells act like well-trained enemies in hijacking a plethora of molecules ...
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A sustained neuroinflammatory response is the hallmark of many neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, and HIV-associated neurodegeneration. A specific subset of T cells, currently recognized as FOXP3+CD25+CD4+ regul...
Background Studies reveal that regulatory T (T reg ) cells control immune responses; therefore these responses must be controlled to enable effective protection against infections and cancer. CCR4 knockout ( CCR4 -/- ) mice are more resistant to lipopolysaccharide shock. So, our aim is to study...
The role of T regulatory cells (Treg) in the induction and maintenance of allograft tolerance is being studied to a great extent. In contrast, little is kn... Yannick,D.,Muller,... - 《Xenotransplantation》 被引量: 73发表: 2009年 T regulatory cells in xenotransplantation. The role of T...
The role of regulatory T cells in the pathogenesis of sepsis and its clinical implication. J Interferon Cytokine Res. 32, 341-349.Jiang,L.-N. Yao,Y... Jiang,L.-N.,Yao,... - 《Journal of Interferon & Cytokine Research the Official Journal of the International Society for Interferon & ...
Regulatory T cells may suppress antibody formation and cytotoxic T cell responses and may be critical for immune tolerance to therapeutic proteins. In this regard, CD4+CD25+ regulatory T cells have been identified as important components of tolerance in several gene transfer protocols, including ...
Natural CD4+CD25+ Tregs express LAG-3 upon activation, which is significantly enhanced in the presence of effector cells, whereas CD4+CD25+ Tregs from LAG-3−/− mice exhibit reduced regulatory activity. Lastly, ectopic expression of LAG-3 on CD4+ T cells significantly reduces their ...
Following infection, CD4+T cell help is necessary for the induction of a memory CD8+T cell pool capable of mediating protective immunity but is largely dispensable for a robust primary response. Regulatory T (TReg) cells act during the resolution phase of infection to protect CD8+T cells from...
Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and it is produced by some populations of regulatory T cells (called IL-10-secreting regulatory T cells), as well as by antigen-presenting cells. It is an attractive candidate for the treatment of allergic asthma. Some existing therapie...