Regulatory T cells (TReg cells) have a central role in immune regulation, but how do they work? In this Review, our current understanding of the suppressive mechanisms used by TReg cells is described and the relative contribution of these mechanisms to T
Regulatory t cells are key in maintaining self-tolerance and immune cell homeostasis, as well as regulating immune responses responsible for autoimmune diseases.
Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for the development of effective strategies for treating tumors and chronic infections. The molecular processes that occur in responder T cells that are suppressed by Treg cells are unclear. Here we show that human Tr...
A workshop entitled "Regulatory T cells (T(reg)) and HIV/AIDS" was held in Cincinnati, OH, September 7-8, 2006. This workshop was the first completely dedicated to T(reg) in HIV infection, and gathered investigators working on different aspects of T(reg) biology, and on HIV pathogenesi...
Regulatory t cells are key in maintaining self-tolerance and immune cell homeostasis, as well as regulating immune responses responsible for autoimmune diseases.
In these models, Tregs are effective at quenching the autoreactive response of conventional T cells, reducing the strength of the autoreactive process [27], [28], [29]. Additional protective effects are also apparent, with compromised remyelination in Treg-deficient mice, and evidence that the ...
T regulatory cells (Tregs) are immunosuppressive subsets of CD4+ T cells, characterized by the expression of the master regulatory transcription factor, Forkhead box protein P3 (FoxP3), which plays an indispensable role in regulating Treg differentiation and development [[1], [2], [3]]. Tregs...
In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth,
Researchers have evidence that the specialized T cells responsible for maintaining a balanced immune response are vulnerable to exhaustion that disrupts normal functioning and may even contribute to allergic reactions. St. Jude Children's Research Hospit
Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9, 91–105 (2009). Article CAS PubMed Google Scholar Reiner, S.L. Development in motion: helper T cells at work. Cell 129, 33–36 (2007). Article CAS PubMed Google Scholar Szabo, S.J. et al. A novel ...