Regulatory T cells (TReg cells) have a central role in immune regulation, but how do they work? In this Review, our current understanding of the suppressive mechanisms used by TReg cells is described and the relative contribution of these mechanisms to T
Regulatory t cells are key in maintaining self-tolerance and immune cell homeostasis, as well as regulating immune responses responsible for autoimmune diseases.
Regulatory t cells are key in maintaining self-tolerance and immune cell homeostasis, as well as regulating immune responses responsible for autoimmune diseases.
The FOXP3+CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor d
Induction of Foxp3 expression in nonregulatory T cells does not occur during pathogen-driven immune responses, and Foxp3 deficiency does not impact the functional responses of nonregulatory T cells. Furthermore, T cell-specific ablation of Foxp3 is sufficient to induce the identical early onset ...
RNA was also isolated from 6.5 CD4+ T cells at days 2, 3, and 4 postadoptive transfer for chip analysis. HA-specific T cells show increasing unresponsiveness to in vitro stimulation from days 2–4. This development of anergy correlates with the acquisition of suppressive activity in in vitro...
Regulatory T cells (Tregs) are an immunosuppressive subpopulation of CD4+ T cells that are endowed with potent suppressive activity and function to limit immune activation and maintain homeostasis. These cells are identified by the hallmark transcription
As the understanding of skeletal muscle inflammation is increasingly clarified, the role of Treg cells in the treatment of skeletal muscle diseases has attracted more attention in recent years. A consensus has been reached that the regulation of Treg cel
In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth,
Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed, thereby promoting the immune cells to migrate into the brain, suggesting that the immune responses can play a vital role in the pathology of IS. As an essential sub