Rudensky Principles of regulatory T cell function Immunity, 56 (2023), pp. 240-255, 10.1016/j.immuni.2023.01.004 View PDFView articleView in ScopusGoogle Scholar 119 K. Wing, Y. Onishi, P. Prieto-Martin, T. Yamaguchi, M. Miyara, Z. Fehervari, T. Nomura, S. Sakaguchi CTLA-4 control...
Single-cell chromatin accessibility reveals principles of regulatory variation. Nature. 2015;523:486-90.Buenrostro, J. D. et al. Single-cell chromatin ... JD Buenrostro,B Wu,UM Litzenburger,... 被引量: 0发表: 0年 Impact of the X Chromosome and sex on regulatory variation To resolve the...
As I mentioned in the Introduction, this chapter may seem not to have an overall objective, but it introduces ideas and topics that I consider important. These topics are presented in a basic format that may seem logical to some readers, and strange and out of context to others. All these...
To test this hypothesis, we first examined DNase I hypersensitive sites (DHSs) across 55 mouse tissues and cell lines15 to measure the chromatin accessibility of each TF OS among different tissues. Because DHSs are a proxy for regulatory element activity19, TF OS regions accessible in multiple...
Describing, or relating to, a regulatory cell that secretes a soluble molecule into an intercellular space, from which it diffuses to a nearby target cell other than the one that produces it. Reactive interstitial compartment A connective tissue that responds to neighbouring stimuli such as inflamma...
Basic principles of tumor-associated regulatory T cell biology. Trends Immunol. 2013; 1 :33–40. doi: 10.1016/j.it.2012.08.005. [ Cross Ref ]Savage, P.A., Malchow, S., and Leventhal, D.S. (2013). Basic principles of tumor-associated regulatory T cell biology. Trends Immunol. 34, ...
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila Cell, 144 (2011), pp. 214-226, 10.1016/j.cell.2010.12.026 View PDFView articleGoogle Scholar 10 K. Isono, T.A. Endo, M. Ku, D. Yamada, R. Suzuki, J. Sharif, T. Ishikura, T. Toyoda, B.E. Bernstein, ...
The brain is an immune-privileged organ such that immune cell infiltration is highly regulated and better tolerating the introduction of antigen to reduce
leading to significant therapeutic advancements across a wide range of diseases. This review summarizes the fundamental molecular mechanisms and regulatory pathways underlying ferroptosis, including both GPX4-dependent and -independent antioxidant mechanisms. Additionally, we examine the involvement of ferroptosis...
Regulatory T cells (Treg cells). A subpopulation of immunosuppressive T cells important for maintaining self-tolerance and homeostasis. Cellular pleiotropy Pleiotropy arising from the ability of one molecule to stimulate multiple distinct cell types or tissues. Functional pleiotropy Pleiotropy arising from ...