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recruitment and activation of not only effector T and B cells but also Tregs, and that the balance between the two populations is critical for the proper control of the quality and magnitude of adaptive immune responses and for establishing or breaching tolerance to self- and non-self-antigens...
Regulatory T Cells and Immune Tolerance in the Intestine A fundamental role of the mammalian immune system is to eradicate pathogens while minimizing immunopathology. Instigating and maintaining immunological tol... OJ Harrison,FM Powrie - 《Cold Spring Harbor Perspectives in Biology》 被引量: 52发表...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendoc...
Regulation by CD4+CD25+ T cells is one of the mechanisms used in vivo to both induce and maintain transplantation tolerance. Alloantigen-specific regulatory T (TReg) cells can be generated either in vivo or ex vivo. TReg cells are found in the graft, as well as in the peripheral lympho...
CD4CD25regulatory T (T) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking Tcells develop severe autoimmune disease, and depletion of Tcells in lymphopenic mice induces autoimmunity. Interleukin (IL)-2 signaling is required for thymic development, peripheral ...
Foxp3: a critical regulator of the development and function of regulatory T cells ShoheiHori,ShimonSakaguchi, inMicrobes and Infection, 2004 Regulatory T cellsare capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regula...
Regulatory T cells(Treg) play an important role in the pathogenesis of organ transplantation,allergic reaction,tumor immunity and infection immunity,etc.It has been demonstrated that Tregs can maintain peripheral immune tolerance by the complicated mechanism to control the extent of cell-mediated immunity...
Dendritic cells (DC), professional antigen-presenting cells of the immune system, exert important functions both in induction of T cell immunity, as well as tolerance. It is well established that the main function of immature DC (iDC) in their in vivo steady-state condition is to maintain per...
In autoimmune disorders such as Multiple Sclerosis (MS) one of the determining alteration is the breakdown of self-antigen immune-tolerance. Peripheral immune tolerance is maintained, at least in part, by Regulatory T cells (Treg). Several studies have shown that either defects in the frequency ...