Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell. 133:775-787. doi:10.1016/ j.cell.2008.05.009Bilate AM, Lafaille JJ. Induced CD4 (+) Foxp3 (+) regulatory T cells in immune tolerance. Annu Rev Immunol 2012;30:733-58 [23...
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from ...
recruitment and activation of not only effector T and B cells but also Tregs, and that the balance between the two populations is critical for the proper control of the quality and magnitude of adaptive immune responses and for establishing or breaching tolerance to self- and non-self-antigens...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-lin...
www.nature.com/mi REVIEW Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry Brianna R. Traxinger1,2, Laura E. Richert-Spuhler2 and Jennifer M. Lund 1,2 ✉ © The Author(s), under exclusive licence to Society for Mucosal ...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation ...
FOXP3regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related diseases, cancer and obesity, there is increasing interest in targeting the Treg cell compartment therapeutically. New pharmacological inhibitors that specifically target the pro...
Regulatory T cells (Tregs) are a subset of CD4 + T cells that express the transcription factor FOXP3 and have an immunosuppressive function [5] and have a critical role in the maintenance of immune tolerance [6]. Downregulation of Foxp3 expression is regarded as common cause of immune ...
自身免疫性疾病的发生具有相关性.它可以通过细胞接触依赖机制和抑制性细胞因子依赖机制主动抑制自身免疫中的T细胞活化,维持自身免疫耐受,防止自身免疫病的发生.CD4+CD25+ Regulatory T cells are involved in immune response and immune response in the body's cells, and have the function of immune adjustment or...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendo...