To improve the quality of patient survival, a new therapeutic strategy that has fewer side effects than current immunosuppressive regimens and can induce allograft immune tolerance and effectively prevent trans
recruitment and activation of not only effector T and B cells but also Tregs, and that the balance between the two populations is critical for the proper control of the quality and magnitude of adaptive immune responses and for establishing or breaching tolerance to self- and non-self-antigens...
FOXP3regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related diseases, cancer and obesity, there is increasing interest in targeting the Treg cell compartment therapeutically. New pharmacological inhibitors that specifically target the pro...
www.nature.com/mi REVIEW Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry Brianna R. Traxinger1,2, Laura E. Richert-Spuhler2 and Jennifer M. Lund 1,2 ✉ © The Author(s), under exclusive licence to Society for Mucosal ...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendocrinopathy enteropathy X-link...
Regulatory T cells (Treg) are critical to the maintenance of self-tolerance and immune cell homeostasis, which is demonstrated by the severe consequences of a lost or nonfunctional Treg population, as occurs in immune dysregulation polyendo...
自身免疫性疾病的发生具有相关性.它可以通过细胞接触依赖机制和抑制性细胞因子依赖机制主动抑制自身免疫中的T细胞活化,维持自身免疫耐受,防止自身免疫病的发生.CD4+CD25+ Regulatory T cells are involved in immune response and immune response in the body's cells, and have the function of immune adjustment or...
th17细胞和调节性t细胞与母胎免疫耐受的关系 correlation of th17 cells and regulatory t cells with maternal-fetal immune tolerance 下载积分: 2000 内容提示: 上海交通大学学报( 医学版)ofShanghai J i aoto“ g U ni versi ty( M edi cal Sci ence)J ournal[ 文章编号]1674—8115( 2012) 11—1525—...
Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
Deletion of autoreactive cells during T- and B-cell development allows the immune system to be tolerant of most self-antigens. Peripheral tolerance to self was suggested several years ago to result from the induction of anergy in peripheral self-reactive lymphocytes. More recently, however, it ...