The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation...
Regulatory T cells (Treg cells) deficient in the transcription factor Foxp3 lack suppressor function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 deficiency dysregulates metabolic checkpoint kinase mammalian target of rapamycin (mTOR) complex 2 (mTORC2) signaling...
Wing, K., Onishi, Y., Prieto-Martin, P. et al. 2008. CTLA-4 control over Foxp3(+) regulatory T cell function. Science 322:271.Smith M,Touriqny MR,Noakes P,Thornton CA,et a1.Children with egg allergy have evidence of reduced neonatal CD4(+)CD25 (+)CD127(1o/一)regulatory T ...
T Cells | Definition, Types & Function7:53 Regulatory T-Cells: Definition & Function Ch 5.Basics of Heredity Ch 6.Function & Roles of DNA Ch 7.Genetic Technologies Ch 8.Acids, Bases & Chemical... Ch 9.Hydrocarbon & Benzene in Organic... ...
However, whether ATLL cells actually function as Treg cells has not yet been clearly demonstrated. Here, we show that ATLL cells from a subset of patients are not only hypo-responsive to T-cell receptor-mediated activation, but also suppress the proliferation of autologous CD4+ non-ATLL ...
CD4+regulatory T cells require CTLA-4 for the maintenance of systemic tolerance These results demonstrate that CTLA-4 is absolutely required for FOXP3(+) regulatory T cell function in vivo.RandallH.Friedline... Randall,H.,Friedline,... - 《Journal of Experimental Medicine》 被引量: 335发表:...
It is widely accepted that the primary immune system contains a subpopulation of cells, known as regulatory T cells whose function is to regulate the immune response. There is conflicting biological evidence regarding the ability of regulatory cells to lose their regulatory capabilities and turn into...
Critically, RelB within APCs was required for the expansion of donor helper T cell type 1 (Th1) effectors and subsequent alloreactivity, but not the peripheral expansion or function of donor FoxP3+ regulatory T cells. These data suggest that the targeted inhibition of nuclear RelB translocation...
Foxp3: a critical regulator of the development and function of regulatory T cells ShoheiHori,ShimonSakaguchi, inMicrobes and Infection, 2004 Regulatory T cellsare capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regula...
CD28/CTLA‐4/B7 costimulatory pathway blockade affects regulatory T‐cell function in autoimmunity 来自 Semantic Scholar 喜欢 0 阅读量: 76 作者:I Vogel,A Kasran,J Cremer,YJ Kim,L Boon,SW Van Gool,JL Ceuppens 摘要: Nave T cells require B7/CD28 costimulation in order to be fully activated. ...