Feinberg MB, Silvestri G: T(S) cells and immune tolerance induc- tion: a regulatory renaissance? Nat Immunol 2002, 3:215-217.Feinberg MB, Silvestri G.T(S) cells and immune tolerance induction:a regulatory renaissance[J]? Nat Immunol,2002,3(3) :215-217....
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from ...
Regulatory T cells (Tregs) play a role in the induction and maintenance of tolerance, as well as in modulating aberrant immune responses. While expanded Tregs have been used in clinical trials, they are polyclonal and the frequency of specific Tregs is very low. To overcome this issue, we ...
A healthy immune system is tolerant to self-antigens while maintaining responsiveness to foreign threats. Co-expression of the inhibitory receptors PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4+T cells independently of thymic selection. ...
immune system, particularly NK T cells 8 and gd T cells.9,10 IFNg is the hallmark cytokine for Th1 cells and CD8 þ T cells and is critical for cell-mediated immunity and cell-mediated adaptive immune responses which are important for immuno- surveillance.11 In humans, the presence of ...
Dendritic-cell precursors traffic through the liver, but resident liver cells, including Kupffer cells, liver sinusoidal endothelial cells and hepatocytes, might be involved in antigen presentation also. Presentation of antigen in the liver can result in either T-cell priming or T-cell tolerance. The...
& Ono, M. Regulatory T cells and immune tolerance. Cell 133, 775–787 (2008). Article CAS PubMed Google Scholar Buckner, J. H. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10, 849–859 (2010). Article CAS...
T cells are the main adaptive immune cell subset resident in the epidermal and dermal layers of the skin. αβ T cells, including CD8+ and CD4+ cells, are skin-resident memory cells with antimicrobial, antitumor, or regulatory functions. The vast majority of γδ T cells reside in the epi...
immune tolerance, preventing autoimmunity against self antigens. Of recent interest have been immune checkpoint inhibitors targeting T cell receptors, such as PD-1 and CTLA-4, which have been successful in un-inhibiting T cell activation and proliferation of antigen-experienced T cells in the tumor...
美国南卡罗莱纳医科大学霍林斯癌症中心研究员Leonardo Ferreira博士和他的合作者在Frontiers in Immunology期刊上发表了一篇标题为“Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance”的论文,描述了他利用表达嵌合抗原受体的Treg细胞(CAR-Treg)解决移...