type 1 regulatory cellsType 1 regulatory T (Tr1) cell is a special type of T regulatory cells with surface molecular markers such as lymphocyte‐activation gene 3 and CD49b. A key property of Tr1 cells is the capability to produce high‐level interleukin 10 (IL‐10) upon activation, in ...
Many types of T cells with regulatory activity have been described in mice and humans, and those within the CD4 + subset have been extensively characterized. CD4 + Type-1 regulatory T (Tr1) cells produce high levels of IL-10 and mediate IL-10-dependent suppression, whereas the effects of ...
Type 1 regulatory (Tr1) T cells are characterized by their immunosuppressive activity and cytokine secretion profile; however, their isolation and enumeration are limited by the absence of specific markers. Here Richard Flavell, Maria-Grazia Roncarolo an
One of the first types of Treg cell populations described was characterized by the high expression of the anti-inflammatory cytokine interleukin-10 (IL-10) and named T regulatory type 1 (Tr1) cells (Roncarolo et al., 1988, Groux et al., 1997). The suppressive function of both mouse and...
Chronic antigenic stimulation can trigger the formation of interleukin 10 (IL-10)-producing T-regulatory type 1 (TR1) cells in vivo. We have recently shown that murine T-follicular helper (TFH) cells are precursors of TR1 cells and that the TFH-to-TR1 cell transdifferentiation ...
Type 1 regulatory (Tr1) T cells are characterized by their immunosuppressive activity and cytokine secretion profile; however, their isolation and enumeration are limited by the absence of specific markers. Here Richard Flavell, Maria-Grazia Roncarolo an
Type 1 regulatory T (Tr1) cells play an important role in maintaining peripheral tolerance. Upon stimulation through TCR, Tr1 cells produce IL10 but not IL4 nor IFNγ, which are distinct from Th2 or Th1 subpopulations. The molecular mechanisms by which Tr1 cells regulate immune responses are ...
IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells 来自 学术范 喜欢 0 阅读量: 18 作者: HL Buanec,ML Gougeon,A Mathian,P Lebon,JM Dupont,G Peltre,P Hemon,M Schmid,B Bizzini,T Künding ...
Tr1 cell (DAPI+CD4+CD49b+LAG-3+, white) is identified in the dermis of psoriasis nonlesional skin. Scale bar = 100 μm. Tr1 cell, type 1 regulatory T cell; Treg cell, regulatory T cell. DAPI, 4',6-diamidino-2-phenylindole. The proportion of activated (CD69+) T cells in CD3+...
revealed that IFN-γ and TNF-α producing activated CD4+ T cells (CD3+CD4+CD44+ T cells) were significantly higher in the spleen of IRF7−/− mice than those of WT mice, while the percentage of the IL-2 and IL-10 producing CD4+ T cells in the spleen and dLN were similar (Fig...