EOMESTr1-like cells, but not Tcells, were clonally related to effector T cells and were clonally expanded in primary and metastatic tumors, which is consistent with their proliferation and differentiation in situ. Using chitinase-3-like protein 2 as a subset signature, we found that the EOMES...
Conclusions 1,25(OH)2D3 inhibits the pathogenic Th17 phenotype in CCR6+ Th cells, while inducing a regulatory Tr1-like phenotype. These cells will then migrate towards the site of inflammation, where they are less potent activators of RASF. This effect of 1,25(OH)2D3 on CCR6+ Th cells...
The aim of this work was to investigate the interactions of tumor cells with dendritic cells (DC) in normal donors and patients with multiple myeloma (MM). Normal and MM DC internalized necrotic lysates derived from myeloma cell lines (MCL) with high efficiency, whereas necrotic lysates from pr...
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tr1-like cells producing and using il-13. the present invention relates to a tr1-like cell population capable of producing il-13, said population having immunosuppressive activities; methods for identifying / isolating / enriching said population and using it.ARNAUD FOUSSAT...
- detecting the production of IL-13, or IL13 and IL-10, wherein the cells expressing CD4 and a low level of CD127 and/or a low level CD62L and producing 1) more than 10ng/mL IL-13 when activated or 2) IL-10 and more than 10ng/mL IL-13 when activated, are the IL-13 prod...
EOMES Tr1-like cells, but not Treg cells, were clonally related to effector T cells and were clonally expanded in primary and metastatic tumors, which is consistent with their proliferation and differentiation in situ. Using chitinase-3-like protein 2 as a subset signature, we found that the ...
The present invention relates to an isolated Tr1-like cell population capable of producing IL-13, the population having immunosuppressive activities; methods for identifying/isolating/enriching the population and its uses thereof.Arnaud FoussatHerve BastianValerie BrunBrigitte Quatannens...
The present invention relates to an isolated Tr1-like cell population capable of producing IL-13, said population having immunosuppressive activities; methods for identifying/isolating/enriching said population and its uses thereof.阿尔诺·福萨特埃尔韦·巴斯蒂安瓦莱丽·布鲁恩布里吉特·夸坦尼恩斯...
Since these factors did not affect CD4+ T cell proliferation in the absence of DCs our data suggest, that Tr1(-like) cell clones rather negatively regulate the stimulatory capacity of DCs leading to a reduced expansion of Ag-specific CD4+ T cells. Therefore these Tr1(-like) cells might ...