It is reported that the frequency of Th1-like Treg cells, which has low suppressive function, increased in autoimmune diseases [2]. T cells Immunoglobulin and TIMI domain (TIGIT) is a co-inhibitory receptor, which can suppress the response of effector T cells. It is identified that the ...
Treg cells coexpress genes that are also expressed by the effector cells they control.Depending on the type of response they control,Treg cells are classified as Th1-like(controlling type I responses),Th2-like(controlling type II responses),or Th17-like(controlling type III responses).Many ...
We noticed that the proportion of Treg cells within the T cells was also increased in the PBC group (Supplementary Fig. 8b and Supplementary Data 4). To verify this result, we performed flow cytometry on liver biopsies of early stage PBC patients and healthy control samples, revealing a ...
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune diseaseautoimmunityFoxp3IFNγplasticityTregsFoxp3+ regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (...
Therefore, a loss of BCATc may generate Th1-like Treg cells and point to its regulatory role in the differentiation of CD4+ T cells.The Journal of ImmunologyTanner WetzelChristie AdamRebekah BetarMike BoyerElitsa Ananieva
(4) aortic endothelial cells activated by proatherogenic stimuli secrete several Th subset-promoting cytokines; (5) in Treg from follicular Th (Tfh)-transcription factor (TF) Bcl6 KO mice, various Th subset regulators were upregulated; whereas in Treg from Th2-TF GATA3 KO mice and HDAC6 ...
Here, we show that human regulatory T cells are particularly sensitive to the sequential effects of IFN-伪. First, IFN-伪 exerts a rapid, antiproliferative and proapoptotic effect in vitro and in vivo, as early as after 2 d of pegylated IFN/ribavirin therapy in patients with chronic ...
Molecular mechanisms underlying Th1-like Treg generation and function. Cell Mol Life Sci 2017.Kitz A, Dominguez-Villar M (2017) Molecular mechanisms underlying Th1-like Treg generation and function. Cell Mol Life Sci 74(22):4059-4075Kitz A, Dominguez-Villar M. Molecular mechanisms underlying Th1...
Kornete M, Mason ES, Girouard J, Lafferty EI, Qureshi S and Piccirillo CA: Th1‑Like ICOS+ Foxp3+ treg cells preferentially express CXCR3 and home to β‑Islets during pre‑diabetes in BDC2.5 NOD mice. PLoS One 10: e0126311, 2015....
Conclusions Our study indicates that IFN-γ secreted from Th1-like Treg cells negatively modulates ACRdoi:10.1016/j.imbio.2016.09.012Xiaoguang Xu PhDHaiyan Huang PhDQiang Wang MDMing CaiYeyong Qian MDYong Han MDXinying Wang MDYu GaoMing Yuan MD...