Sphingosine-1-phosphate (S1P) signalling molecules are upregulated in Th1-like Tregs, and in vivo S1P inhibition with Fingolimod (FTY720) inhibits the expression of genes responsible for Treg plasticity in MS patients. However, the underlying mechanisms are unknown. Here we show that S1P ...
et al. Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-gamma secreting cells. J. Autoimmun. 94, 143–155 (2018). Article CAS PubMed Google Scholar Cordell, H. J. et al. An international genome-wide meta-analysis of ...
Th subset regulators were downregulated, suggesting that Bcl6 inhibits, GATA3 and HDAC6 promote, Treg plasticity; and (6) GATA3 KO, and Bcl6 KO Treg upregulated MHC II molecules and T cell co-stimulation receptors, suggesting that GATA3 and BCL6 inhibit Treg from becoming novel APC-Treg....
Resting and activated subpopulations of CD4 CD25 CD127 lo T regulatory cells (Treg) and CD4 CD25 CD127 effector T cells in MS patients and in healthy ... ND Verma,AD Lam,C Chiu,... - 《Scientific Reports》 被引量: 0发表: 2021年 加载更多来源...
Although there is no significance of statistical analysis due to the limited number of samples, CD8/Treg ratio showed increased pattern in CD4-Chi3l1 KO mice, which is clinically critical value for successful immunotherapy18,19 (Supplementary Fig. 3). However, IFNγ producing T cells from spleen...
Mice with Treg-restricted deletion of the IFNγ receptor (IFNGR1, Ifngr1L/LFoxp3Cre-YFP) or the IL12 receptor β2 subunit (IL12Rβ2, Il12b2L/LFoxp3Cre-YFP), were infected with the acute (Armstrong), or chronic (Clone 13), strain of lymphocytic choriomeningitis virus (LCMV). ...
Th1-like TregTIGITSequence effectThe induction direction of interferon (IFN)-α in T-cell phenotype and function varies depending on the activation state of the cell and the time of stimulation. To assess the effects of elevated IFN-α on regulatory T cells (Tregs) in systemic lupus ...
The function of FOXP3+ regulatory T (Treg) cells in maintaining immune balance under these conditions is still controversial.Using a murine CM model, we found that Tregs massively accumulate in the mouse brain, suppressing lethal immune pathology and neurological deterioration during CM. Brain-...
As CXCR3 confers the preferential trafficking of T cells to tissue sites of IFN-γ, these human Th1-like Treg might be useful for modulating pathological Th1 effector responses, such as that occurring during graft-versus-host disease or graft rejection. © 2011 WILEY-VCH Verlag GmbH & Co. ...
Notably, the Th1-like Treg cell-to-Foxp3−Th1 cell ratio was significantly lower in ACR patients compared with that in stable controls. In graft biopsies from ACR patients, Treg cells and Th1-like Treg cells were less abundant than those without ACR. Our study indicates that IFN-γ ...