Thus, ARDS is actually a TH17-like and Treg immune disorder.doi:10.48550/arXiv.1311.4384Wan-Chung Huquantitative biologyHu, W.-C. Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease. arXiv preprint arXiv:1311.4384 (2013)....
To identify different cytokine- producing T cells subsets [Th1 (CD3+/CD4+ INF-γ+), Tc-1 (CD3+/CD8+ INF-γ+), Th17 (CD3+/CD4+ IL-17+), Th17.1 (CD3+/CD4+ INF-γ+IL-17+), Tc-17 (CD3+/ CD8+ IL-17+) and Treg-like cells (CD3+CD4+IL-10+], ...
Here, in imiquimod-induced psoriasis-like mice, MLT supplementation reduced skin inflammation and corrected the Th17/Treg cell imbalance. Network pharmacology and proteome sequencing analyses revealed that MLT attenuates the inflammatory response in the skin of psoriatic mice by inhibiting the PI3K/Akt ...
Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum 2012; 64: 2499–2503. Article CAS PubMed Google Scholar van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM et al. Th17 cells, ...
TregCD39SerotoninREGULATORY T-CELLSGM-CSFIMMUNE-RESPONSESDISEASE-ACTIVITYMood disorders have been associated with risk of clinical relapses in multiple sclerosis (MS), a demyelinating disease mediated by myelin-specific T cells.We aimed to investigate the impact of major depressive disorder (MDD) and...
By contrast, the percentage of TLRs(+)Treg17 cells (IL-10(+)IL-17(+)) was negatively related to sCD14 and the severity of NMOSD. In conclusion, the expansion of peripheral IL-6-producing TLR(+) Th17-like cells in NMOSD patients was associated with both bacterial translocation and ...
The proportion of Th17 in mesenteric lymph nodes increased while Treg decreased in the model group. BG treatment effectively reduced the conversion of Treg to Th17. Additionally, BG was found to enhance mitophagy and activate the PPARγ/NF-κB signaling. BG demonstrates promising effects in ...
Treg and Th17 profiles. Both share TGFβ as an inductive stimulus but differ in which cytokine accompanies it: IL-10 for the Treg profile and IL-6 for the Th17 profile [57]. Interestingly, IL-6 also propitiates re-polarization processes in an unidirectional way (from Treg to Th17) [58]...
Meanwhile, soluble fibrinogen–like protein 2 (Sfgl2) is a critical immunosuppressive effector cytokine of Treg cells and modulates immune responses. However, the impact of SAP induction on Sfgl2 expression and the role of Sfgl2 in immunomodulation under SAP conditions are largely unknown. Methods ...
Conclusions In summary, our findings suggested that recurrent major depression, by favoring imbalances of effector Th17 and Treg cell subsets, contributes to MS severity. Ethical approval The work was approved by the Ethics Committee for Research on Human Subjects of the Federal University of the Sta...