Regulatory T (Treg) cells maintain immune homeostasis by inhibiting excessive immune responses. Treg cells control a variety of immune responses, which vary according to the nature of the infection or insult. Treg cells were once thought to be stable; however, many studies now suggest that they ...
Since their ‘re-discovery’ more than two decades ago, FOXP3+regulatory T cells (Tregs) have been an important subject of investigation in the biomedical field and our understanding of the mechanisms that drive their phenotype and function in health and disease has advanced tremendously. During t...
Conclusions PD-1 blockade promotes the expansion of a subset of highly-activated Treg cells coexpressing PD-1 and Helios. While these cells are potently suppressive outside tumor environments, costimulatory and inflammatory signals present in the tumor microenvironment lead to their local acquisition of...
We previously demonstrated that tumor necrosis factor (TNF)-alpha-matured CD16- and CD16+ human monocyte-derived dendritic cells (16-mDC and 16+mDC) differ... RC Amaranta,Meraz-Ríos Marco A.,SA Leopoldo,... - 《International Immunology》 被引量: 72发表: 2004年 TCR-independent activation...