gamma delta T cells share characteristics of innate and adaptive immune cells and are involved in a broad spectrum of pro-inflammatory functions. Nonetheless, there is accumulating evidence that gamma delta T cells also exhibit regulatory functions. In this review, we describe the different phenotypes...
The gammadelta T cells consisted almost entirely of Vgamma6/Vdelta1+ cells, a murine subset bearing an invariant TCR the function of which is still unknown. Treatment of C57BL/6 mice with heat-killed vs live B. subtilis resulted in a 2-fold increase in the number of CD4+ T cells in...
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acidipiscis was lost in γδ T cell-deficient mice and hence was concluded to depend on the presence of regulatory γδ T cells in the intestinal epithelium. Moreover, including L. acidipiscis enhanced the development of Vγ1+γδ T cells but suppressed that of Vγ4+γδ T cells. In ...
Furthermore, senescent T cells and DCs induced by γδ Treg cells had altered phenotypes and impaired functions and developed potent suppressive activities, further amplifying the immunosuppression mediated by γδ Treg cells. In addition, we demonstrated that manipulation of TLR8 signaling in γδ ...
Defining the suppressive mechanisms used by regulatory T (Treg) cells is critical for the development of effective strategies for treating tumors and chronic infections. The molecular processes that occur in responder T cells that are suppressed by Treg
MAIT cells, DC cells, macrophages, and LSECs exhibit dual roles in MASLD progression. Innate immune functions in MASLD are exerted by hepatocytes and LSECs. In the adaptive immune responses, effector T cells such as Th17 cells, Th1 cells, and cytotoxic CD8+ T cells enhance immune-mediated ...
T-cells play an important role controlling immunity against pathogens and therefore influence the outcome of human diseases. Although most T-lymphocytes co-express either CD4 or CD8, a smaller T-cell subset found the in the human peripheral blood that ex
TFR cells were found to control TFH13 cell-induced IgE. In vivo, loss of TFR cells increased house-dust-mite-specific IgE and lung inflammation. Thus, TFR cells control IgG and IgE responses to vaccines, allergens and autoantigens, and exert critical immunoregulatory functions before GC ...
1997), mutation of the p53 suppressor gene (Jiang et al. 1996), or overexpression of the antiapoptotic bcl-2 transgene (Linette et al. 1994) in RAG−/− mice. TCRγδ expression also impacts αβ T cell development. αβ lineage cells, including DP cells and mature αβ T cells, ...