The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation...
由于 pTreg 在Foxp3基因表观修饰和效应分子表达上稳定性更差,并不适合作为细胞治疗的原料;而通过初始 CD4 阳性 T 细胞(Naïve CD4+T 细胞)诱导得到的 iTreg 细胞以及 tTreg 细胞,在体外也具有良好的增殖能力和稳定的抑制功能,...
Regulatory T cells: mechanisms of differentiation and function. The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal ... SZ Josefowicz,LF Lu,AY Rudensky - 《Annual Review of Immunology》 被引量: 0...
Regulatory T (T(reg)) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses. Foxp3 operates as a late-acting differentiation factor controlling T(reg) cell homeostasis and function, whereas ...
Y. Regulatory T cells: mechanisms of differentiation and function. Annu Rev. Immunol. 30, 531–564 (2012). Article CAS PubMed PubMed Central Google Scholar Annunziato, F., Romagnani, C. & Romagnani, S. The 3 major types of innate and adaptive cell-mediated effector immunity. J. ...
Interestingly, a two-day protocol using expression of CD25 and CD134 (OX-40) on effector T cells has been shown to correlate with proliferation and can serve as a shorter, surrogate measurement of suppressive function of Treg. Table 2. Reagents for in vitro e...
Table 2. Reagents forin vitroexpansion of tTreg. MediatorsFunction Anti-CD3TCR crosslinking Anti-CD28Co-stimulation Gibco CTS (Cell Therapy Systems) Dynabeads CD3/CD28TCR crosslinking and co-stimulation IL-2Growth factor RapamycinSuppress exp...
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation Our experiments indicate that the accumulation of CD4+CD25+regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function origin... Ghiringhel...
PeripheralregulatoryT-cells/pTreg(adaptive/induced/a/iTreg) InvitrogeneratedregulatoryT-cells/iTreg NOMENCLATURE EARLYEXPERIMENTALMODELSSUGGESTINGTHEPRESENCEOFREGULATORYT-CELLS ThymicregulatoryT-cells(SakaguchiS.) Function: Maintenanceofnaturalself-tolerance ...
immune control memory CD8 T cells microenvironment magnesium Mg2+ co-stimulation/LFA-1 integration of microenvironment and T cell function tumor-specific T cells CAR T cells T cell engaging antibodies Introduction Low dietary Mg2+ intake and hypomagnesemia have been implicated in the pathophysiology of...