The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation...
Regulatory T (T(reg)) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses. Foxp3 operates as a late-acting differentiation factor controlling T(reg) cell homeostasis and function, whereas ...
O. Regulatory T-cells: potential regulator of tissue repair and regeneration. Front. Immunol. 9, 585 (2018). PubMed PubMed Central Google Scholar Liu, W. et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203, ...
Regulatory T cells(Tregs) are a subset of CD4+T cells that produce anti-inflammatory cytokines, such as IL-10 and TGFβ, which function to limit the activation of other immune cells and thus prevent excessive activity of the immune system in response to microbes or to self-antigens[108–11...
Stable Foxp3 expression ensures Treg function in a variety of inflammatory contexts. However, the model of Treg cells as a stable, long-lived lineage is controversial. Whereas some studies have observed long-lived Treg function, recent studies suggest that Treg cells adapt to microenvironmental ...
由于 pTreg 在Foxp3基因表观修饰和效应分子表达上稳定性更差,并不适合作为细胞治疗的原料;而通过初始 CD4 阳性 T 细胞(Naïve CD4+T 细胞)诱导得到的 iTreg 细胞以及 tTreg 细胞,在体外也具有良好的增殖能力和稳定的抑制功能,...
(I) T reg cells (TR) isolated from R23CTg or WT control littermates were subjected to in vitro suppression analysis at indicated ratios of responder T cells (TE). Data are representative of three independent experiments. n = 6. (J) Percentages of mice (∼5 mo of age) with ...
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Table 2. Reagents forin vitroexpansion of tTreg. MediatorsFunction Anti-CD3TCR crosslinking Anti-CD28Co-stimulation Gibco CTS (Cell Therapy Systems) Dynabeads CD3/CD28TCR crosslinking and co-stimulation IL-2Growth factor RapamycinSuppress e...
Table 2. Reagents forin vitroexpansion of tTreg. MediatorsFunction Anti-CD3TCR crosslinking Anti-CD28Co-stimulation Gibco CTS (Cell Therapy Systems) Dynabeads CD3/CD28TCR crosslinking and co-stimulation IL-2Growth factor RapamycinSuppress exp...