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We found that Helios probably is a better marker than Nrp-1 for distinguishing tTreg cells from pTreg cells and that there are more IL-10+, Ebi3+and CTLA-4+cells among Helios+tTreg cells. Delgoffe et al. have reported that Nrp1 is required for the stability and functionality of Treg ...
The expression of these markers in some cases of mycosis fungoides/Sezary syndrome suggests follicular center helper T-cell differentiation and may lead to confusion in distinguishing mycosis fungoides/Sezary syndrome from other follicular center helper T-cell marker positive T-cell lymphomas with ...
(2006) this article describes the use of CD127 (IL-7 receptor subunit-α) as a surface marker, the exclusion of which dramatically enhances peripheral blood human T reg cell purity after FACS. CAS PubMed PubMed Central Google Scholar Ohkura, N., Kitagawa, Y. & Sakaguchi, S. Development...
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (2007) The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566–569 Comin-Anduix B, Escuin-Ordinas H, Ibarrondo FJ (2016) Tremelimumab: research an...
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As for the source of these different Treg cells, they are indeed diversified in the origins, and can be generally divided into thymus derived Treg cells (tTreg cell), peripheral Treg cells generated by Foxp3-T cells (pTreg cell) and induced Treg cells (iTreg cell) in vitro [1, 27]....
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10.meister,g.e.,etal.,“twonoveltcellepitopepredictionalgorithmsbasedonmhc-bindingmotifs;comparisonofpredictedandpublishedepitopesfrommycobacteriumtuberculosisandhivproteinsequences”,vaccine,13(6):581-591(1995). 11.partidos,c.d.,etal.,“immuneresponsesinmicefollowingimmunizationwithchimericsyntheticpeptidesrepr...