In plants as in animals, the Rb-E2F pathway represents the major target,its activation triggers transcription of abattery of genes involved in cell cycle control, DNA replicationand cell metabolism. Recent molecular and genetic studies uncovered critical roles of the G1/S cell-cyclemachinery and ...
The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis. Adv Cancer Res 2014;121: 147-82.Schaal C, Pillai S and Chellappan SP. The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis. Advances in cancer research. 2014; 121:147-182....
Group 4: There was one case of Rb protein loss with an HR-HPV-positive status.#HR-HPV and Rb/p16/p53 pathway can be associated in MANEC pathogenesis, which provides the research basis for personalized treatment of MANEC.Wolters Kluwer - MedknowIndian Journal of Pathology and MicrobiologyFeng...
and activation of the Rb/E2F1 pathway was obviously suppressed.To conclude,the SENEX gene promotes proliferation in PBMC and tumor cells of DLBCL patients by activating the Rb/E2F1 pathway,in a manner suggesting that increased SENEX expression affects the relapse of DLBCL and may serve as an ...
CDKN2B is a cell-cycle regulator that controls G1/S transition and regulates the RB/E2F pathway.25 Therefore, we constructed a psi-Check2 vector containing the 3′ UTR sequence of CDKN2B, and the luciferase assay results showed that overexpressing MEX3A inhibited the firefly luciferase ...
and genes associated with proliferation and apoptosis were upregulated. This study shows that HBZ protein promotes cell proliferation and apoptosis in primary CD4+T cells through activation of the Rb/E2F pathway, and that HBZ protein also confers onto CD4+T-cell immunophenotype similar to those of...
Role of the Rb/E2F pathway in cell growth control. J Cell Physiol. 1997 Nov;173(2):233-6. Review JR Nevins,G Leone,J Degregori,... - 《Journal of Cellular Physiology》 被引量: 156发表: 2015年 The Rb/E2F pathway and cancer. Questions remain, however, as to the specific role ...
The RB/E2F pathway plays an essential role in cell cycle regulation and maintenance of cellular homeostasis (14, 15). Mutations in genes within this pathway are found at high rates in almost all types of cancer, attesting to their importance in cell growth control (15, 16). RB and its st...
HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4(+) T cells. Oncogene. 2016; 35(34):4509-17. PubMed Central PMCID: PMCPMC4959989. doi: 10.1038/onc.2015.510 PMID: ... A Kawatsuki,JI Yasunaga,Y Mitobe,... - 《Oncogene》 ...
Human VIPRl genes are identified as modulators of the E2F/RB pathway, and thus are therapeutic targets for disorders associated with defective E2F/RB function. Methods for identifying modulators of E2F/RB, comprising screening for agents that modulate the activity of VIPRl are provided....