In plants as in animals, the Rb-E2F pathway represents the major target,its activation triggers transcription of abattery of genes involved in cell cycle control, DNA replicationand cell metabolism. Recent molecular and genetic studies uncovered critical roles of the G1/S cell-cyclemachinery and ...
e2f与rb结合将抑制自身激活转录的能力，这说明rb阻碍基因表达有赖于与e2f的结合。rb间接地阻止了细胞进入s期，rb-e2f则是直接阻止了这些基因的表达，其解离则促使这些基因的表达。某些病毒性肿瘤抗原特异性与非磷酸化rb结合，如sv40大t抗原和腺病毒的e1a。肿瘤抗原与rb结合，使得rb-肿瘤抗原复合物不能结...
RB蛋白表现为细胞周期、细胞生长和分化的中心环节。RB通过与转录因子E2F结合来抑制细胞增殖并使其失去活性。在G0/G1阶段,HDAC1被招募到含有E2F/口袋蛋白复合物的启动子。在RB抑制的G1/S进程中,HDAC1取代口袋蛋白,允许转录激活。RB/...
视网膜母细胞瘤蛋白RB是一种肿瘤抑制因子,可参与调控细胞周期、DNA损伤反应和细胞分化等。RB有非磷酸化、部分磷酸化和高度磷酸化三种存在形式,非磷酸化和/或部分磷酸化的RB可与E2F相互作用,抑制E2F靶基因的表达和G1/S期转换,而在有丝分裂原的刺激...
These results further suggested that silencing of TRAIP may induce G1/S arrest by repressing the RB-E2F signaling pathway. Transwell assay and scratch test were performed to determine the effect of TRAIP gene knockdown on cell migration/invasion. The results of scratch test displayed that the ...
Role of the Rb/E2F pathway in cell growth control. J Cell Physiol. 1997 Nov;173(2):233-6. Review JR Nevins,G Leone,J Degregori,... - 《Journal of Cellular Physiology》 被引量: 156发表: 2015年 The Rb/E2F pathway and cancer. Questions remain, however, as to the specific role ...
HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4(+) T cells. Oncogene. 2016; 35(34):4509-17. PubMed Central PMCID: PMCPMC4959989. doi: 10.1038/onc.2015.510 PMID: ... A Kawatsuki,JI Yasunaga,Y Mitobe,... - 《Oncogene》 ...
Li, T. et al. Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.Artif. Cells Nanomed. Biotechnol.47, 4001–4011 (2019). ArticleCASPubMedGoogle Scholar ...
Targeting the RB-E2F pathway in breast cancer. Oncogene. 2016;35(37):4829–35. Article CAS PubMed PubMed Central Google Scholar Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic ...
whereas the phosphorylations of p53, p21 and p27 were not affected by FGF9. Moreover, FGF9‐ induced effects were inhibited by MEK inhibitor PD98059, indicating FGF9 activated the Rb/E2F pathway to accelerate MA‐10 cell...