Ben May Department for Cancer ResearchSearleBen May Department for Cancer ResearchJ. S.Ben May Department for Cancer ResearchCurrent Drug TargetsDu W,Searle J S.The Rb pathway and cancer therapeutics..Current Drug Targets. 2009Du W, Searle JS. The rb pathway and cancer therapeutics. Curr Drug...
Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation.The cancer-associated loss of microRNA (miRNA) expression leads to a proliferative advantage and aggressive behavior through largely unknown mechanisms. Here, we exploit a model system that recapitulates physiological...
Nrf2 has a dark side in that cancer cells can use a mutated form of this pathway to protect themselves against the body’s immune system and chemotherapeutic agents. Mutations in the Keap1-Nrf2 pathway can lead to fast growing and highly resistant tumor growths.11, 12 ...
The Rb-E2F transcrip- tional regulatory pathway in tumor angiogenesis and metas- tasis. Advances in cancer research. 2014; 121:147-182.Schaal C, Pillai S, Chellappan SP (2014) The Rb-E2F tran- scriptional regulatory pathway in tumor angiogenesis and metastasis. Adv Cancer Res 121:147-182...
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tu
Expression of the genes encoding MVA pathway enzymes is controlled by the sterol regulatory element-binding protein (SREBP) family of transcription factors. In cancer cells, oncogenic signalling pathways deregulate the activity of the SREBP transcription factors and MVA pathway enzymes. Deregulated producti...
Recent works have also identified several other critical functions of the cGAS–STING pathway, which may also be involved in antiviral mechanisms and other chronic disease responses. For example, the cGAS–STING pathway was demonstrated to have a role in cancer and lipid metabolism as well as in...
The RB/E2F pathway plays an essential role in cell cycle regulation and maintenance of cellular homeostasis (14, 15). Mutations in genes within this pathway are found at high rates in almost all types of cancer, attesting to their importance in cell growth control (15, 16). RB and its st...
Cancer is caused by a combination of genetic and epigenetic abnormalities. Current cancer therapies are limited due to the complexity of their mechanism, underlining the need for alternative therapeutic approaches. Interestingly, combining the Clustered
Pathways upstream of TOR are frequently activated in cancer. This can be through increased activity of phosphatidylinositol-3-kinase–AKT or kinases that regulate TSC2, or through mutations that inactivate TSC proteins. The TOR pathway is also upregulated in many human cancers and oncogenic transforma...