Johnson J, Thijssen B, McDermott U, Garnett M, Wessels LF, Bernards R. Targeting the RB-E2F pathway in breast cancer. Oncogene. 2016;35:4829-35.Johnson, J.; Thijssen, B.; MscDermott, U.; Garnett, M.; Wessels, L.F.; Bernards, R. Targeting the rb-e2f pathway in breast cancer. ...
In cancer, the CDK4/CDK6–RB–p16INK4A pathway is dysregulated through various mechanisms, including loss of p16INK4A, loss of RB, overexpression of cyclin D1 or of CDK4 and CDK6. Clinical trials with pan-CDK inhibitors, such as flavopiridol, have demonstrated low levels of clinical activ...
HOXB9, as a HOX family transcription factor, playing a significant role in embryonic development and cancer progression. However, the function of HOXB9 and its precise mechanism in regulating endometrial cancer progression remains unknown. Here, we demonstrated that the expression of HOXB9 was increas...
The cyclin D/cyclin-dependent kinase (CDK)4/6/retinoblastoma (Rb) Pathway and the cell cycle. The mammalian cell cycle is tightly regulated. In the context of breast cancer, both steroid and peptide growth factors drive proliferation through cyclin D/CDK4/6 activation. This results in the hyp...
Association of abnormal kinase expression with breast cancer Alterations in the PI3K/AKT/mTOR pathway are particularly prevalent in breast cancer, with estimates indicating that up to 70% of tumors exhibit some form of genetic mutation that leads to the hyperactivation of this pathway. The PI3K/AKT...
Proteasome inhibitors (PIs) are a class of compounds, which either reversibly or irreversibly block the activity of proteasomes and induce cancer cell death. Interference of PIs with the ubiquitin proteasome pathway (UPP) involved in protein turnover in the cell leads to the accumulation of ...
AR signaling pathway and targeted therapeutic approaches in PCa. Androgen synthesis is regulated by the hypothalamic–pituitary–gonadal axis. When androgens such as testosterone (T) and DHT bind to AR, AR releases itself from the heat shock protein complex, translocates into the nucleus, and promot...
PROTAC has emerged as a promising approach for targeted therapy in various diseases, particularly in cancers. In this review, we introduce the principle and development of PROTAC technology, as well as the advantages of PROTACs over traditional anti-cancer therapies. Moreover, we summarize the ...
Moreover, restoration of miR-141 in c-Myc knockdown NPC cells notably rescued the effect of c-Myc on cell proliferation and tumor growth, as well as the blocking of PTEN/AKT pathway. Additionally, the expression of c-Myc was positively correlated with that of miR-141 and the clinical ...
macrophage migration inhibitory factor (MIF), inhibit the activation of p53- and Rb-E2F pathways and thereby promote tumorigenesis [16,17]. The various components involved in inflammatory processes form a positive feedback loop that supports cancer progression. The inflammatory cytokines and growth ...